Naslov
Therapeutic Perspectives of IL1 Family Members in Liver Diseases: An Update

Autori
Ćurčić, Ines Bilić ; Kizivat, Tomislav ; Petrović, Ana ; Smolić, Robert ; Tabll, Ashraf ; Wu, George Y. ; Smolić, Martina

Izvornik
Journal of clinical and translational hepatology (2225-0719) 10 (2022), 6; 1186-1193

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
ALCOHOLIC STEATOHEPATITIS ; INFLAMMASOME ACTIVATION ; COLORECTAL-CANCER ; DANGER SIGNALS ; IMMUNE CELLS ; URIC-ACID ; IL-33 ; HEPATITIS ; INTERLEUKIN-1 ; INJURY

Sažetak
Interleukin (IL) 1 superfamily members are a cornerstone of a variety of inflammatory processes occurring in various organs including the liver. Progression of acute and chronic liver diseases regardless of etiology depends on the stage of hepatocyte damage, the release of inflammatory cytokines and disturbances in gut microbiota. IL1 cytokines and receptors can have pro- or anti- inflammatory roles, even dual functionalities conditioned by the microenvironment. Developing novel therapeutic strategies to block the IL1/IL1R signaling pathways seems like a reasonable option. This mode of action is now exploited by anakinra and canakinumab, which are used to treat different inflammatory illnesses, and studies in liver diseases are on the way. In this mini review, we have focused on the IL1 superfamily members, given their crucial role in liver inflammation diseases, specifically discussing their potential role in developing new treatment strategies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA