Naslov
Chromosomal abnormalities in childhood lymphomas

Autori
Petković, Iskra ; Ćepulić, Mladen ; Konja, Josip ; Vrdoljak, Javor.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Medical and Pediatric Oncology / International Society of Pediatric Oncology - Istanbul : Wiley-Liss, 1997, 458-458

Skup
SIOP XXIX. Meeting

Mjesto i datum
Istanbul, Turska, 23.09.1997. - 27.09.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cytogenetics; lymphoma; children

Sažetak
This study presents the results of cytogenetic analysis in children with malignant lymphoma. The aim of this investigation was to define the frequency abd types of clonal chromosomal abnormalities in malignant cells in our group of childhood non-Hodgkin's lymphoma.Our investigation included 16 children, 4 girls and 12 boys aged from 9 nmonths to 15 years.Cytogenetic analysis of malignant cells was carried out at diagnosis and before initiating therapy. Slides were obtained from direct or short-term culture of lymphonode, and / or bone marrow cells. Chromosome identification was carried out using the G-banding method. Chromosomal abnormalities were described according to the International System for Human Cytogenetic Nomenclature (1991). Cytogenetic analysis revealed clonal chromosomal abnormalities in 11 (68.7%) out of 16 children.Chromosomal instability and evidence of clonal evolution were observed in 3 patients. Pseudodiploid clone was observed in 4, hyperdiploid in 5 and hypotriploid in 2 out of 11 children with clonal chromosomal aberrations. This investigation revealed complex numerical and structural aberrations. the gain of some chromosometypes were nonrandom and frequently affected chromosomes were 11, 14, 21, and X. involvement of particular chromosome tapes in structural abnormalities was nonrandom too. Chromosome No.1 and No.14 were abnormal in 5 and 4 cases respectively. This investigation confirms variability of clonal chromosomal aberrations and cytogenetic heterogeneity of childhood non-Hodgkin lymphomas. Additional investigations are, however , necessary to define more presisely the frequency and types of aberrations, and biological role of chromosomal regions in the development of NHL.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA