Naslov
Changes in plasma lipids after a non-lethal dose of cycloheximide in rats

Autori
Lucić, Ana ; Bradamante, Vlasta ; Peraica, Maja ; Radić, Božica ; Domijan, Ana-Marija ; Fuchs, Radovan

Izvornik
Human and Experimental Toxicology (0960-3271) 22 (2003); 245-248

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cikloheksimid; HDL; Kolesterol; sinteza proteina; ukupni kolesterol; trigliceridi
(cycloheximide; protein synthesis; triglycerides; total cholesterol; HDL-cholesterol)

Sažetak
This paper describes a study of the effect of a single intraperitoneal non-lethal dose of cycloheximide (CHM ; 2.0 mg/kg body weight) on the concentration of plasma lipids and lipoproteins in male rats killed 1, 2, 3, 4 and 9 days after receiving the dose. The concentration of triglycerides, total cholesterol, high-density lipoproteins (HDL)-cholesterol and low-density lipoproteins (LDL)-cholesterol was measured in treated and control animals. The effect of CHM on the concentration of triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol was visible in rat plasma throughout the study. Total cholesterol and HDL-cholesterol concentrations showed the same pattern of changes, probably due to the reversible inhibition of apolipoprotein apo A-I synthesis by CHM. The concentration of triglycerides decreased after a lag period of 3 days when the reserves of apolipoprotein apo B, the main apolipoprotein of very low-density lipoproteins (VLDL)-cholesterols produced in liver, were consumed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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