Naslov
Povezanost upalnih parametara i infekcija krvi uzrokovanih multirezistentnim Gram negativnim bakterijama kod COVID-19 pozitivnih bolesnika liječenih u jedinici intenzivnog liječenja – retrospektivna studija jednog centra
(Correlation between inflammatory parameters and bloodstream infections caused by multidrug resistant Gram-negative bacteria in critically ill COVID-19 patients – retrospective single-center study)

Autori
Sakan, Sanja ; Kralik, Kristina ; Mihelčić, Antonija ; Hleb, Sonja ; Blagaj, Vanja ; Čučković, Marcela ; Dobrović, Karolina ; Mikecin, Verica ; Kristović, Darko ; Desnica, Marina ; Sojčić, Nataša ; Bradić, Nikola ; Šribar, Andrej ; Šafarić Oremuš, Zrinka ; Peršec, Jasminka

Izvornik
Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora (0024-3477) 144 (2022), Supp 3; 31-36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
covid-19 ; gram negativne bakterije ; acinetobacter baumannii ; klebsiella
(covid-19 pandemics ; gram-negative bacteria ; acinetobacter baumannii ; klebsiella)

Sažetak
Objectives: During the COVID-19 pandemics we have seen in critically ill COVID-19 patients treated in the intensive care unit the parallel outbreak of multidrug resistant Gram-negative bacteria bloodstream infections, mainly Acinetobacter baumannii and Klebsiella pneumoniae. Methods: We conducted a retrospective cohort single-center study. The aim was to investigate the incidence, etiology and impact of intensive care unit bloodstream infections in COVID-19 patients admitted to the COVID-19 intensive care unit with a known burden of multidrug resistance and to evaluate the possibility that inflammatory parameters levels measured at two different time points of treatment can early predict multidrug resistant Gram- negative bacteria bloodstream infections and enable timely beginning of bacterial targeted antimicrobial therapy. Results: Our study confirmed that procalcitonin values of 2, 46 mcg/L and neutrophil/lymphocyte ratio of 28, 9 could be a reliable indicators for high risk stratification of multidrug resistant Gram- negative bacterial infection origin in critically ill COVID-19 patients (Mann Whitney U test, P=0, 02). Conclusion: Monitoring dynamic shift of inflammatory parameters in critically ill COVID-19 patients could reliably help clinician to recognize the multidrug resistant Gram-negative bacteria bloodstream infections and start with the antimicrobial therapy in a timely manner.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA