Naslov
The effects of moderate red wine consumption on arterial stiffness and hemodynamic parameters in type 2 diabetes mellitus

Autori
Mudnić, Ivana ; Nazlić, Jurica ; Boban, Zvonimir ; Gujinović, Diana ; Dželalija, Ana Marija ; Boban, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
10th Croatian Congress of Pharmacology with International Participation and 1st Croatian Congress of Clinical Pharmacology with International Participation, Pharmaca 2022 ; 52 Suppl 2 / Mršić-Pelčić, Jasenka ; Vitezić, Dinko ; Janković, Tamara - Zagreb, 2022, 160-160

Skup
10. hrvatski kongres farmakologije ; 1. hrvatski kongres kliničke farmakologije s međunarodnim sudjelovanjem = 10th Croatian Congress of Pharmacology ; 1st Croatian Congress of Clinical Pharmacology and Therapeutics with International Participation

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
red wine ; arterial stiffness ; hemodynamic parameters ; type 2 diabetes mellitus

Sažetak
Introduction Assessment of carotid-femoral pulse wave velocity (PWV), a direct measure of arterial stiffness, could serve as useful tool in the early detection of type 2 diabetes mellitus (T2DM) patients at high risk of cardiovascular events. Moderate red wine consumption has been linked to cardiovascular benefits among both healthy persons and diabetic patients. We aimed to determine whether the daily intake of a 300 ml of red wine for 3 weeks affect PWV and hemodynamic parameters in T2DM patients. Subjects and Methods In the 5- weeks cross-over interventional trial of 18 T2DM participants we assessed changes in PWV and hemodynamic parameters (heart rate, peripheral and central systolic, diastolic and pulse pressures). All participants underwent an initial 2 weeks- drive in period with no alcohol consumption (baseline) followed by 3-weeks of wine consumption period. The measurements were performed at the end of each period by applanation tonometry using the SphygmoCor® device. Results Moderate RW consumption was associated with significant decrease in PWV from 7.42±1.44 m/s at baseline to 6.98±1.44 m/s at the end of wine consumption period. Peripheral arterial diastolic pressure also decreased from baseline 79.72±11.47 mmHg to 76.39±11.15 mmHg at the end of wine consumption period. Conclusion In a cohort of diabetic patients without clinical symptoms of cardiovascular disease, relatively short period of moderate red wine consumption resulted in improvement of cardiovascular hemodynamics.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA