Naslov
Prostate cancer and environmental exposure to toxic metal(loid)s: impact on prostate specific antigen (PSA)
(Prostate cancer and environmental exposure to toxic metal(loid)s: impact on prostate specific antigen (PSA))

Autori
Pizent, Alica ; Tariba Lovaković, Blanka ; Živković Semren, Tanja ; Gamulin, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
“HDIR-6: targeting cancer” : book of abstracts / Ozretić, Petar - Zagreb : Hrvatsko društvo za istraživanje raka (HDIR), 2022, 46-46

ISBN
978-953-48672-1-1

Skup
“HDIR-6: targeting cancer” The 6th meeting of the Croatian association for cancer research with international participation

Mjesto i datum
Zagreb, Hrvatska, 10.11.2022. - 12.11.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
prostate cancer ; PSA ; blood metal concentration ; toxic metals ; SOD ; GPx

Sažetak
Prostate cancer is among the most commonly diagnosed malignancies in men and its incidence increases with age. In addition to family history, race, and ethnicity, various external risk factors may contribute to its increased risk. Arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) are pervasive environmental contaminants and several experimental and epidemiological studies linked exposure to these metal(loid)s with an increased risk of prostate cancer. However, research on the impact of low-level exposure is scanty and largely inconclusive. Prostate specific antigen (PSA), combined with a digital rectal examination of prostate, has been routinely used for early detection of prostate cancer in spite of its insufficient specificity for clinically important cancers. Moreover, several studies in presumably healthy men indicated that various external factors can affect PSA levels, including metal(loid) exposure. Therefore, we aimed to evaluate the role of environmental exposure to As, Cd, Pb and Hg in prostate cancer risk and their impact on serum PSA. Blood As, Cd, Pb, and Hg and serum PSA were measured in 62 prostate cancer patients and 30 control men with no occupational exposure to metals. Prostate cancer patients had significantly higher serum PSA and blood Hg than control subjects. The results of Spearman’s correlation and a simple linear regression analysis in all 92 subjects showed a positive association between blood Hg and PSA. However, after control for the impact of the remaining elements in the models of multiple regression, this association was lost. Although we did not confirm a linear association between measured metal(loid)s and PSA in conditions of environmental exposure, further investigation in larger cohorts, taking into consideration possible synergistic or non-linear mixture effects, are warranted.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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