Naslov
Brain-gut miscommunication: Irritable bowel syndrome

Autori
Tkalčić, Mladenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
14th Alps-Adria Psychology Conference (AAPC2022)

Mjesto i datum
Milano, Italija, 05.09.2022. - 09.09.2022

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sindrom iritabilnoga crijeva, os crijeva-mozak
(irritable bowel syndrome, gut-brain axis)

Sažetak
It is well known that the brain and the gastrointestinal system are closely linked through bidirectional signalling pathways that include nerves, hormones, and inflammatory molecules, and that dysregulation of this brain-gut axis could lead to functional gastrointestinal (GI) disorders, such as irritable bowel syndrome (IBS). IBS is one of the most common functional GI disorders characterized by abdominal pain and stool irregularities. IBS is considered a biopsychosocial disorder and its symptoms could result from any combination of altered GI motility, visceral hypersensitivity, increased intestinal permeability, immune activation of the bowel mucosa, alteration in the microbiota, and disturbances in brain-gut function. The brain-gut axis (CNS, central nervous system – ENS, enteric nervous system) is the neuroanatomic substrate by which psychosocial factors influence the GI tract and vice versa. IBS symptoms are often maintained by a vicious cycle of physical, behavioural, and environmental factors that disrupt the neural connections between the brain and gut. Using the Biopsychosocial Conceptual Model of functional GI disorders, the goal of this lecture is to give an overview of our research results and to discuss them in the context of recent understanding on how the complex interactions of biological, psychological, and environmental factors contribute to the development and maintenance of IBS, with an emphasis on the brain- gut interaction.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA