Naslov
Prevalence and profile of congenital heart defects in children with Down syndrome – experience of southwestern Bosnia and Herzegovinian 16 years
(Prevalence and profile of congenital heart defects in children with Down syndrome – experience of southwestern Bosnia and Herzegovinain 16 years)

Autori
Pupić-Bakrač, Jure ; Bozic, Tomica ; Mikulic-Kajić, Matija ; Pupić-Bakrač, Ana ; Didović Pavičić, Ana ; Kovačević, Petra

Izvornik
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics (1330-0091) 23 (2016), 3; 97-101

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
: congenital heart defect, congenital ; Down syndrome

Sažetak
Introduction. Congenital heart defects (CHD) are the largest cause of death in newborn patients with Down syndrome (DS), and their prevalence in DS at the global level is 40–50%. However, the overall prevalence of CHD and the prevalence of certain types of CHD in DS varies signifi cantly between different geographic regions. In Western countries, the highest incidence has AVSD, in Latin America ASD, in Asia VSD, and in Africa and the Middle East PDA. The cause of such distribution is unknown. Materials and methods. Retrospective cohort study was conducted over 85 subjects with diagnosed DS. Cystogenic and echocardiographic fi ndings were used from medical history to analyze the prevalence and distribution of CHD in DS. Also, data on different demographic factors were used to investigate their impact on prevalence. Results. Of 85 respondents 83, 5% (N = 71) had CHD (χ2 = 38, 224 ; P < 0, 001). Of those 46, 48% (N = 33) had hemodynamically signifi cant CHD (χ2 = 0, 352 ; P = 0, 553). The most frequent CHD were ASD (77, 46%), followed by PDA (35, 21%), AVSD (18, 31%) and VSD (18, 31%). Out of all CHDs 59, 15% of them were isolated, and 40, 85% were multiple. Conclusion. The results of the overall prevalence and the prevalence of certain types of CHD in our study differs from the results of other authors from Europe. Ethiopathogenesis should be further investigated. The application of the results of this study should, in addition to the clinical findings in practice, serve as an assistance in CHD screening in DS. Early setting of accurate diagnosis and application of therapy are key to improve the survival of patients with DS.

Izvorni jezik
Engleski

POVEZANOST RADA