Naslov
Chlamydia pneumoniae infection and atherosclerosis in chronic renal insufficiency: A brief communication

Autori
Kovacic Vedran

Izvornik
Dialysis & transplantation (0090-2934) 33 (2004); 724-731

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Chlamydia pneumoniae, chronic renal insufficiency

Sažetak
The bacterium Chlamydia pneumoniae may trigger the cascade of biological and biochemical reactions leading to chronic inflammation and atherosclerosis. The role of C. pneumoniae on atherogenesis may be limited to the beginning stage of atherosclerosis development. C. pneumoniae generally is sensitive to antibiotic therapy. Despite some controversial results, few studies have demonstrated that antibiotic therapy with azithromycin, clarithromycin, and roxithromycin has the potential to improve the immunological, serological, and clinical status in patients with atherosclerosis. The chronic inflammation may cause malnutrition and progressive atherosclerosis in chronically dialyzed patients. Investigations have confirmed that one of the sources of inflammation and atherosclerosis in dialysis patients could be C. pneumoniae. Despite the high level of chronic inflammation and C. pneumoniae seropositivity in end-stage renal disease and chronically dialyzed patients, there has not been any trial that has looked at the influence of antibiotics on chronic inflammation status, C. pneumoniae markers, or clinical outcomes in these patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA