Naslov
A comparison of low-flux cellulose acetate and polysulfone dialyzers: Impact on plasma lipid concentration in chronic hemodialysis patients

Autori
Kovacic, Vedran ; Roguljic, Luka ; Kovacic, Vinko

Izvornik
Dialysis & transplantation (0090-2934) 32 (2003), 9; 552-558

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dialysis, lipids

Sažetak
Purpose. Patients on chronic hemodialysis have plasma lipid abnormalities. The effect of low-flux membranes on the plasma lipids is controversial. We undertook a study to examine the effects on lipid profiles between two low-flux dialysis membranes with similar characteristics but different compositions. Subjects & Methods. Subjects consisted of 23 anuric patients. For the first 9 months, all subjects were dialyzed with a cellulose acetate low-flux dialyzer (Plivadial 18, Pliva, Zagreb, Croatia) ; for the last 9 months, they were switched to a polysulfone low-flax dialyzer (Fresenius F6, Fresenius, Bad Homburg, Germany). Blood samples were taken 6 times, in 3- month intervals. Results. Significant differences were found in plasma lipid concentrations between the cellulose and polysulfone dialysis groups with regard to the following: high-density lipoprotein cholesterol (HDL-C), 1.07 +/- 0.24 us. 1.41 +/- 0.48 mmol/L (p = 0.001) ; low-density lipoprotein cholesterol (LDL-C), 3.37 +/- 0.85 vs. 2.76 +/- 1.01 mmol/L (p = 0.002) ; total cholesterol/HDL-C ratio, 5.17 +/- 1.51 vs. 4.08 +/- 1.87 (p = 0.005) ; and LDL-C/HDL-C ratio, 3.38 +/- 1.42 vs. 2.37 +/- 1.56 (p = 0.001). Significant differences were also found following sequential lipid testing of six samples taken throughout the study period with regard to: plasma cholesterol concentration (p = 0.001), HDL-C concentration (p = 0.015), LDL- C concentration (p = 0.001), total cholesterol/HDL ratio (p = 0.022), and LDL/HDL ratio (p = 0.023). Conclusion. The data demonstrate improvements in the lipid parameters (decreases in LDL-C and total cholesterol, and increases in HDL-C) after switching from cellulose acetate to polysulfone dialyzers. The choice of dialyzer membrane may have an effect on plasma lipids and the atherogenic process.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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