Naslov
To give or not to give? A critical appraisal of a clinical trial on radioiodine treatment

Autori
Tuncel, Murat ; Vrachimis, Alexis ; Campenni, Alfredo ; de Keizer, Bart ; Verburg, Frederik A. ; Kreissl, Michael C. ; Ovcaricek, Petra Petranovic ; Geliashvili, Tamara ; Giovanella, Luca

Izvornik
European Journal of Nuclear Medicine and Molecular Imaging (1619-7070) 49 (2022), 10; 3316-3319

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, uvodnik, ostalo

Ključne riječi
thyroid cancer, radioiodine

Sažetak
Recently, Leboulleux et al. published the results of the ESTIMABL 2 trial [1]. It is an open-label, randomised, phase III trial using a noninferiority comparison design. In this study, included patients were at the lowest-risk end of the low-risk spectrum of diferentiated thyroid cancer (DTC) treated with total thyroidectomy with or without lymph node dissection. Patients were randomised to receive low-dose postoperative radioiodine therapy (RAI) with 1.1 GBq in one group and follow-up without RAI in the second group. We congratulate the authors for this work, representing one of the few randomised trials available in the feld. However, we would point out some potential limitations that need to be considered before translating these results to generalised clinical recommendations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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