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Pregled bibliografske jedinice broj: 1228859

Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients

Degoricija, Vesna; Klobučar, Iva; Potočnjak, Ines; Dokoza Terešak, Sanda; Vidović, LUka; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjorg; Madl, Tobias; Frank, Saša
Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients // Biomolecules, 12 (2022), 1542, 12 doi:10.3390/biom12101542 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1228859 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients
(Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients)

Autori
Degoricija, Vesna ; Klobučar, Iva ; Potočnjak, Ines ; Dokoza Terešak, Sanda ; Vidović, LUka ; Pregartner, Gudrun ; Berghold, Andrea ; Habisch, Hansjorg ; Madl, Tobias ; Frank, Saša

Izvornik
Biomolecules (2218-273X) 12 (2022); 1542, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NMR spectroscopy ; acute heart failure ; cholesterol ; mortality ; prognostic biomarkers ; risk ; very-low-density lipoprotein

Sažetak
Considering the relationship between the extent of metabolic derangement and the disease severity in heart failure, we hypothesized that the lipid content of very-low-density lipoprotein (VLDL) may have prognostic value for 1 year mortality in acute heart failure (AHF). Baseline serum levels of VLDL cholesterol (VLDL-C), VLDL triglycerides (VLDL-TG), VLDL phospholipids (VLDL-PL), and VLDL apolipoprotein B (VLDL-apoB) were measured using NMR spectroscopy. We calculated the ratios of the respective VLDL lipids and VLDL apoB (VLDL-C/VLDL- apoB, VLDL-TG/VLDL-apoB, and VLDL-PL/VLDL-apoB), as estimators of the cholesterol, triglyceride, and phospholipid content of VLDL particles and tested their association with mortality. Out of 315 AHF patients, 118 (37.5%) patients died within 1 year after hospitalization for AHF. Univariable Cox regression analyses revealed a significant inverse association of VLDL-C/VLDL-apoB (hazard ratio (HR) 0.43, 95% confidence interval (CI) 0.29-0.64, p < ; 0.001), VLDL-TG/VLDL-apoB (HR 0.79, 95% CI 0.71-0.88, p < ; 0.001), and VLDL- PL/VLDL-apoB (HR 0.37, 95% CI 0.25-0.56, p < ; 0.001) with 1 year mortality. Of the tested parameters, only VLDL-C/VLDL-apoB remained significant after adjustment for age and sex, as well as other clinical and laboratory parameters that showed a significant association with 1 year mortality in the univariable analyses. We conclude that cholesterol content of circulating VLDL (VLDL-C/VLDL-apoB) might be of prognostic value in AHF.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Vesna Degoricija (autor)

Avatar Url Ines Potočnjak (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Degoricija, Vesna; Klobučar, Iva; Potočnjak, Ines; Dokoza Terešak, Sanda; Vidović, LUka; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjorg; Madl, Tobias; Frank, Saša
Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients // Biomolecules, 12 (2022), 1542, 12 doi:10.3390/biom12101542 (međunarodna recenzija, članak, znanstveni)
Degoricija, V., Klobučar, I., Potočnjak, I., Dokoza Terešak, S., Vidović, L., Pregartner, G., Berghold, A., Habisch, H., Madl, T. & Frank, S. (2022) Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients. Biomolecules, 12, 1542, 12 doi:10.3390/biom12101542.
@article{article, author = {Degoricija, Vesna and Klobu\v{c}ar, Iva and Poto\v{c}njak, Ines and Dokoza Tere\v{s}ak, Sanda and Vidovi\'{c}, LUka and Pregartner, Gudrun and Berghold, Andrea and Habisch, Hansjorg and Madl, Tobias and Frank, Sa\v{s}a}, year = {2022}, pages = {12}, DOI = {10.3390/biom12101542}, chapter = {1542}, keywords = {NMR spectroscopy, acute heart failure, cholesterol, mortality, prognostic biomarkers, risk, very-low-density lipoprotein}, journal = {Biomolecules}, doi = {10.3390/biom12101542}, volume = {12}, issn = {2218-273X}, title = {Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients}, keyword = {NMR spectroscopy, acute heart failure, cholesterol, mortality, prognostic biomarkers, risk, very-low-density lipoprotein}, chapternumber = {1542} }
@article{article, author = {Degoricija, Vesna and Klobu\v{c}ar, Iva and Poto\v{c}njak, Ines and Dokoza Tere\v{s}ak, Sanda and Vidovi\'{c}, LUka and Pregartner, Gudrun and Berghold, Andrea and Habisch, Hansjorg and Madl, Tobias and Frank, Sa\v{s}a}, year = {2022}, pages = {12}, DOI = {10.3390/biom12101542}, chapter = {1542}, keywords = {NMR spectroscopy, acute heart failure, cholesterol, mortality, prognostic biomarkers, risk, very-low-density lipoprotein}, journal = {Biomolecules}, doi = {10.3390/biom12101542}, volume = {12}, issn = {2218-273X}, title = {Cholesterol content of very-low-density lipoproteins is associated with 1-year mortality in acute heart failure patients}, keyword = {NMR spectroscopy, acute heart failure, cholesterol, mortality, prognostic biomarkers, risk, very-low-density lipoprotein}, chapternumber = {1542} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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