Naslov
Love or compulsion relationship between myelin basic protein and phosphatidylcholine lipids

Autori
Maleš, Petra ; Brkljača, Zlatko ; Bakarić, Danijela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIV. Susret mladih kemijskih inženjera : knjiga sažetaka = XIV Meeting of Young Chemical Engineers : Book of Abstract / Žižek, Krunoslav ; Katančić, Zvonimir ; Kovačić, Marin - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI),, 2022, 54-54

Skup
14. susret mladih kemijskih inženjera (SMLKI)

Mjesto i datum
Zagreb, Hrvatska, 24.02.2022. - 25.02.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
Phosphatidylcholine ; Liposomes ; MBP

Sažetak
Myelin is a multilayer membrane tightly wrapped around the axon of neurons, allowing efficient transmission of neural impulses. Slight changes in distributions of lipids in myelin membranes affect their adhesive properties, as well as their bonding with myelin basic protein MBP, one of the most important myelin-associated proteins. With its high content of positively charged residues, unstructured MBP binds to the anionic lipids of the cytoplasmic leaflets, which causes balance changes between charged lipids and alternations in the lateral organization of the model myelin bilayers. All these changes appear in neurodegenerative diseases such as multiple sclerosis (MS) and encephalomyelitis (EAE). It is not yet known what role MBP confinement plays in the efficiency of its adsorption to lipid bilayer made from zwitterionic lipid 1, 2-dipalmitoyl-sn- glycero-3-phosphocholine (DPPC), which constitutes about 40% of myelin lipids. Using the several types of calorimetric and spectroscopic techniques, such as FT-IR and CD spectroscopy, UV- Vis spectrometry, ITC and DSC calorimetry our goal is to unravel the impact of MBP on phase transition temperatures (Tp, Tm) of DPPC multilamellar and unilamellar liposomes and their structural arrangements. All experimental results are supported with computational study.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA