Pregled bibliografske jedinice broj: 1228064
Mechanisms of Histone Modifications
Mechanisms of Histone Modifications // Handbook of Epigenetics The New Molecular and Medical Genetics / Trygve Tollefsbol (ur.)., 2022. str. 27-54
CROSBI ID: 1228064 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mechanisms of Histone Modifications
Autori
Vanzan, Ludovica ; Sklias, Athena ; Boskovic, Maria ; Herceg, Zdenko ; Murr, Rabih ; Suter, M. David
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni
Knjiga
Handbook of Epigenetics The New Molecular and Medical Genetics
Urednik/ci
Trygve Tollefsbol
Izdavač
Elsevier
Godina
2022
Raspon stranica
27-54
ISBN
9780323919098
Ključne riječi
Histone modifications ; chromatin ; epigenetics ; acetylation ; methylation ; phosphorylation ; transcription ; DNA repair
Sažetak
In eukaryotic genomes, DNA is condensed in the form of chromatin. While chromatin is fundamentally a protective structure, it constitutes a challenge for all major cellular functions, for which interaction with the DNA sequence is a necessary requirement. posttranslational modifications of nucleosomes, the building blocks of chromatin, contribute to regulate accessibility. Here, we introduce the most common histone modifications, the machineries that deposit and remove them and their distribution in the genome. We also focus on their role in key cellular processes, particularly in transcriptional regulation and DNA repair.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
