Pregled bibliografske jedinice broj: 1227556
Ekološki prihvatljiva sinteza triazola s kumarinskom jezgrom
Ekološki prihvatljiva sinteza triazola s kumarinskom jezgrom // Book of Abstracts 19th Ružička days Today Science - Tomorrow Industry / Babić, Jurislav (ur.). (ur.).
Osijek : Zagreb: Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2022. str. 34-34 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Ekološki prihvatljiva sinteza triazola s kumarinskom
jezgrom
(An eco-friendly route for the synthesis of coumarin
based triazole derivatives)
Autori
Lončar, Mirjana ; Molnar, Maja ; Blangetti, Marco ; Arnodo, Davide ; de Nardi, Federica
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of Abstracts 19th Ružička days Today Science - Tomorrow Industry
/ Babić, Jurislav (ur.). - Osijek : Zagreb : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2022, 34-34
Skup
19. Ružičkini dani "Danas znanost - sutra industrija"
Mjesto i datum
Vukovar, Hrvatska, 21.09.2022. - 23.09.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
eutektička otapala ; kumarin ; triazoli
(deep eutectic solvents ; coumarin ; triazole)
Sažetak
Coumarins and their derivatives have attracted considerable attention due to their extensively biological, pharmacological, biochemical and therapeutic activities. Some authors have shown that the combination of coumarin moiety and some nitrogen-containing heterocycles, such as triazoles, contribute to better biological activity in comparison with initial material. Deep eutectic solvents (DESs) are novel generation of “green solvents” that have proven to be a convenient media for many synthetic pathways. They are often described as environmentally friendly and sustainable mixtures of nontoxic and cheap components, whose properties can be adjusted for various applications. Prompted by the above mentioned facts and in continuation of our on-going interest in the development of new green synthetic approaches, the aim of this study was to synthesize coumarin triazole derivatives from 2-[(4-methyl-2- oxo-2H-chromen-7yl)oxy]acetohydrazide and different isocyanates utilizing ChCl-based DES as a reaction media. In first step, we obtained semicarbazides, which were subjected to cyclization in 2% sodium hydroxide solution under reflux to obtain final product. Our method is more convenient than conventional ones, providing high product yields and cleaner reaction paths.
Izvorni jezik
Engleski
