Naslov
Infection of the newborn and fetus: murine model of pregnancy-associated listeriosis

Autori
Abram, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Publication of the Turkisch Microbiological Society No. 44: Abstracts of Invited and Free Papers / Tumbay, Emel - Izmir : META Press, 2002, 18-19

Skup
FEMS Symposium: The Versatility of Listeria species

Mjesto i datum
İzmir, Turska, 10.10.2002. - 11.10.2002

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pregnancy; placenta; Listeria

Sažetak
The impact of L. monocytogenes infection on the maternal immune response as well as on the outcome of pregnancy was studied in a murine model of pregnancy-associated listeriosis. BALB/c mice infected intravenously with L.monocytogenes on day 15 of pregnancy showed impaired bacterial elimination from the liver. The impaired maternal immune response faciliated bacterial multiplication in the placenta and, ultimately, in the fetus. Placental colonization involved all or only some of the placentas in the same uterus. Despite marked pathohistological changes and numerous bacteria, the imflammatory reaction was confined to single granulocytes, but T cells and other cellular elements necessary for effective antilisterial defence were absent. The severity of placental infection predicted whether the fetus was aborted or resorbed. Listeriae were frequently detected in the tissues of the resorbing fetuses while only occasionally from the tissues of the aborted fetuses. In conclusion, our experimental model proved insufficient maternal immune response to L. monocytogenes during pregnancy. This stresses the necessity of a rapid therapeutic intervention to prevent bacterial multiplication in the placenta.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA