Naslov
CYTOLOGY OF CERVICAL INTRAEPITHELIALGLANDULAR LESIONS

Autori
Ovanin-Rakić, Ana ; Audy-Jurković Silvana ; Mahovlić Vesna ; Škopljanac-Mačina, Lada ; Rajhvajn, Sanda ; Barišić, Ana ; Ilić -Forko, Jadranka ; Folnović, Darko ; Kani, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts Of The 34th European Congress Of Cytopathology / Herbert, A - Lahti : John Wiley & Sons, 2008, 94-95

Skup
34th European Congress of Cytopathology

Mjesto i datum
Rovaniemi, Finska, 15.07.2008. - 18.07.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glandular intraepithelial lesion, cytology

Sažetak
Introduction: Cytological criteria for the identification of glandular intraepithelial lesion have not yet been fully described, especially for the precursors of adenocarcinoma in situ(AIS), thus these lesions may frequently remain unrecognized. As most patients in whom AIS or mild to moderate glandular intraepithelial lesions GIL(grades I and II) is diagnosed are free from clinical symptoms, have normal macroscopic appearance and non-characteristic colposcopical picture, cytology has a very prominent and responsible role in the detection of these lesions. Aim: Cytology findings of patients with histologically verified AIS and GIL (I, II) were analyzed to achieve the most appropriate and accurate cytological diagnosis of intraepithelial lesions of endocervical cylindric epithelium. Patients and methods: The value of cytology in the detection and differential diagnosis was evaluated in 123 patients with definitive histological diagnosis of glandular lesions [AIS (n= 13), GIL I(n= 11), GIL II (n= 7)] and glandular lesions associated with squamous component, [AIS+CIN/IC (n= 58), GIL I/GIL II + CIN(n= 28), GIL+MIC (n= 6)], on the basis of lesion severity and/or type of epithelium affected. Results: In 95.1% (117/123) of patients, lesions were detected by cytological analysis that indicated additional diagnostic procedure. In terms of differential diagnosis, cytology showed higher accuracy in predicting lesion severity versus type of epithelial alteration (93/123 ; 75.6% versus 68/123 ; 55.3%), and abnormalities of squamous versus cylindric epithelium 88/92 ; 95.7% ; versus 23/31 ; 74.2%).The accuracy of cytology was higher in pure than in mixed lesions(AIS- 8/13 ; 61.5% and GIL I, II- 4/18 ; 22.2% versus 15/58 ; 25.9%and 7/34 ; 20.6%).Conclusion: Continuous improvement in cervical specimens and cytodiagnostic skills, better understanding and definition of intra- epithelial adenocarcinoma and precursors, and their inclusion in the classification of cytological and histological cervical findings are expected to upgrade the detection and diagnosis of intraepithelial glandular cervical lesions, and to reduce the invasive cervical adenocarcinoma morbidity and mortality

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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