Naslov
CYTOLOGIC FOLLOW-UP OF WOMEN WITH ABNORMAL PAP TEST ACCORDING TO HIGH RISK HPV-DNA

Autori
Barišić, Ana ; Audy-Jurković Silvana ; Ovanin- Rakić, Ana ; Žele-Starčević, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. HRVATSKI KONGRES PATOLOGIJE I SUDSKE MEDICINE 3. HRVATSKI KONGRES KLINIČKE CITOLOGIJE 1. HRVATSKI SIMPOZIJ CITOTEHNOLOGIJE s meðunarodnim sudjelovanjem Knjiga sažetaka / Jonjić, Nives ; Kardum.Skelin, Ika - Karlovac, 2005, 142-142

Skup
3. HRVATSKI KONGRES PATOLOGIJE I SUDSKE MEDICINE 3. HRVATSKI KONGRES KLINIÈKE CITOLOGIJE 1. HRVATSKI SIMPOZIJ CITOTEHNOLOGIJE s meðunarodnim sudjelovanjem

Mjesto i datum
Opatija, Hrvatska, 08.05.2005. - 11.05.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Cytology, Pap test, HPV, follow-up

Sažetak
Aim of the study. The aim of the study is to provide retrospective correlation of the results of cytologic follow-up in women with abnormal Pap- test finding - cervical intraepithelial neoplasia (CIN) and typing for the human papilloma virus DNA (HPV-DNA). Patients and Methods. At the University Department of Clinical and Molecular Microbiology, Zagreb University Hospital Center, 247 women with abnormal cytologic finding were tested for high risk HPV-DNA by the Digene Hybrid Capture II (HCII) test from June 1, 2000 till May 31, 2001. The Cytologic follow-up of Pap findings was performed at the Department of Gynecologic Cytology, University Department of Gynecology and Obstetrics, Zagreb University Hospital Center over at least a 2-year period on at least 4 Pap findings. The Followup outcome was classified into three categories: regression (R), at least 3 consecutive negative cytologic findings over more than a one-year period ; stagnation (S), unchanged CIN staging ; and progression (P), any higher CIN stage. Results. Out of 247 women tested for high risk HPV-DNA, 61 (24.7%) women underwent cytologic follow-up at our Department over more than 2 years (mean 34.2, range 24-52 months) ; two conizations were not included in the analysis. High risk HPV- DNA was identified in 42 (71.2%) of 59 patients with cytologic follow-up. At the end of cytologic followup, in the group of patients negative for high risk HPV-DNA (n=17), R was recorded in 10 (58.8%), S in 5 (29.4%) and P in 2 (11.8%) patients. In the group of patients positive for high risk HPV-DNA (n=42), R was recorded in 11 (26.2%), S in 26 (61.9%) and P in 5 (11.9%) patients. The rate of stagnation/progression versus regression of cytologic findings was statistically significantly higher in the group of patients positive than in those negative for high risk HPV-DNA (c2=4.288 ; p=0.0384). Conclusion. Stagnation/progression versus regression of cytologic finding is significantly higher in the group of patients positive for high risk HPV-DNA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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