Naslov
RAPID CERVICOVAGINAL SMEAR SCREENING - A QUALITY CONTROL METHOD?

Autori
Audy-Jurković, Silvana ; Pajtler, Marija, Škopljanac-Mačina, Lada ; , Antulov, Jasenka ; Barišić Ana, Miličić-Juhas, Valerija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. HRVATSKI KONGRES PATOLOGIJE I SUDSKE MEDICINE 3. HRVATSKI KONGRES KLINIÈKE CITOLOGIJE 1. HRVATSKI SIMPOZIJ CITOTEHNOLOGIJE s meðunarodnim sudjelovanjem Knjiga sažetaka / Jonjič, Nives ; Kardum.Skelin, Ika - Karlovac, 2005, 141-141

Skup
3. HRVATSKI KONGRES PATOLOGIJE I SUDSKE MEDICINE 3. HRVATSKI KONGRES KLINIÈKE CITOLOGIJE 1. HRVATSKI SIMPOZIJ CITOTEHNOLOGIJE s meðunarodnim sudjelovanjem

Mjesto i datum
Opatija, Hrvatska, 08.05.2005. - 11.05.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
rapid rescreening, Pap smear, quality control

Sažetak
Aim of study. To test the method of rapid rescreening (RR) in detection of cervical lesions and false negative results as well as in cytotechnologist's quality control. Patients and Methods. The RR method was tested on Papanicolaou stained and initially conventionally analyzed vaginal, cervical and endocervical (VCE) swabs. The study included 1640 VCE swabs from laboratory A (Department of Gynecologic Cytology, University Department of Gynecology and Obstetrics, Zagreb University Hospital Center, Zagreb) and 2040 VCE swabs from laboratory B (Department of Clinical Cytology, Osijek University Hospital, Osijek). Histologically verified abnormal cytologic findings accounted for 10% of the samples. The testing was performed by seven cytotechnologists in laboratory A and six cytotechnologists in laboratory B. Each slide was examined by the "step" technique within 1.5 min, the findings were divided into negative and abnormal groups, and the latter were further subdivided according to differential cytologic diagnosis. Results were compared with those obtained by initial screening. Abnormal findings from the group of initially negative findings were analyzed again by the conventional method in order to make definitive cytologic diagnosis. Results. In laboratory A, of 1640 slides 1459 (89.0%) were correctly (1310 or 79.9% of true negative - TN, and 149 or 9.1% of true positive - TP, and 181 (11%) incorrectly (45 or 2.7% of false negative - FN and 136 or 8.3% of false positive - FP diagnosed by RR. In laboratory B, of 2040 slides 1949 (95.6%) were correctly (1759 or 86.2% of TN and 191 or 9.4% of TP), and 91 (4.4%) incorrectly (21 or 1% of FN and 69 or 3.4% of FP) diagnosed by RR. In laboratory A and B, the RR method showed a sensitivity of 76.8% and 90, 1%, specificity of 90.6% and 96.2%, positive predictive value of 52.3% and 73.4%, negative predictive value of 96.7% and 98.8%, and diagnostic accuracy of 88.9% and 95.5%, respectively. According to the initial abnormal differential cytologic diagnosis, the diagnostic value of RR increased with lesion severity. RR detected 30 FN findings in laboratory A and 8 FN findings in laboratory B, most of them in the groups of ASC-US (atypical squamous cells of undetermined significance) and CIN I (cervical intraepithelial neoplasia). The number of FP findings per cytotechnologist ranged from 4.3% to 11.9% in laboratory A, and from 0.9% to 5.0% in laboratory B. The number of FN findings per cytotechnologist ranged from 1.7% to 4.3% in laboratory A, and from 0.0% to 2.1% in laboratory B. Conclusion. RR can be used as an efficient quality control method to increase the sensitivity of cytologic screening and as method of cytotechnologist quality control.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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