Naslov
Scabies in a Patient with Rheumatoid Arthritis Treated with Adalimumab – A Case Report

Autori
Marković, Ivan ; Pukšić, Silva ; Gudelj Gračanin, Ana ; Čulo, Melanie Ivana ; Mitrović, Joško ; Morović-Vergles, Jadranka

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 23 (2015), 3; 195-195

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
rheumatoid arthritis ; tumor necrosis factor alpha ; adalimumab ; hypersensitivity ; scabies ; crotamiton

Sažetak
Rheumatoid arthritis is a chronic systemic inflammatory disease characterized by synovitis, erosions, and destruction of affected joints. If untreated, it leads to severe disability and premature mortality. Tumor necrosis factor alpha (TNF-α) inhibitors are biological drugs used in treatment of rheumatoid arthritis. Possible side effects include skin allergic reactions, which, if generalized, are the reason for discontinuation of the drug. We report the case of a 46-year-old female patient with rheumatoid arthritis who presented with pruritus and erythematous papular exanthema after administration of the second dose of adalimumab. At first, we suspected a drug hypersensitivity reaction. As the signs and symptoms persisted for 2 months after discontinuation of adalimumab and despite continuous administration of antihistamines and glucocorticoids, further work-up was performed, and scabies was diagnosed. The patient was treated with topical 10% crotamiton. The symptoms were persistent and additional applications of the preparation were needed. After clinical remission of scabies, treatment of active rheumatoid arthritis with adalimumab was restarted without any complications.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA