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Pregled bibliografske jedinice broj: 1224978

LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries

(LiverScreen Consortium Investigators) Graupera, Isabel; Thiele, Maja; Ma, Ann T.; Serra-Burriel, Miquel; Pich, Judit; Fabrellas, Núria; Caballeria, Llorenç; de Knegt, Robert J.; Grgurevic, Ivica; Reichert, Mathias et al.
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries // BMC Public Health, 22 (2022), 1; 1385-1385 doi:10.1186/s12889-022-13724-6 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1224978 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries

Autori
Graupera, Isabel ; Thiele, Maja ; Ma, Ann T. ; Serra-Burriel, Miquel ; Pich, Judit ; Fabrellas, Núria ; Caballeria, Llorenç ; de Knegt, Robert J. ; Grgurevic, Ivica ; Reichert, Mathias ; Roulot, Dominique ; Schattenberg, Jörn M. ; Pericas, Juan M. ; Angeli, Paolo ; Tsochatzis, Emmanuel A. ; Guha, Indra Neil ; Garcia-Retortillo, Montserrat ; Morillas, Rosa M. ; Hernández, Rosario ; Hoyo, Jordi ; Fuentes, Matilde ; Madir, Anita ; Juanola, Adrià ; Soria, Anna ; Juan, Marta ; Carol, Marta ; Diaz, Alba ; Detlefsen, Sönke ; Toran, Pere ; Fournier, Céline ; Llorca, Anne ; Newsome, Phillip N. ; Manns, Michael ; de Koning, Harry J. ; Serra- Burriel, Feliu ; Cucchietti, Fernando ; Arslanow, Anita ; Korenjak, Marko ; van Kleef, Laurens ; Falcó, Josep Lluis ; Kamath, Patrick S. ; Karlsen, Tom H. ; Castera, Laurent ; Lammert, Frank ; Krag, Aleksander ; Ginès, Pere ; Alvarez, Marifé ; Andersen, Peter ; Angeli, Paolo ; Ardèvol, Alba ; Arslanow, Anita ; Beggiato, Luca ; Abdesselam, Zahia Ben ; Bennett, Lucy ; Boutouria, Bajiha ; Brocca, Alessandra ; Broquetas, M. Teresa ; Caballeria, Llorenc ; Calvino, Valeria ; Camacho, Judith ; Capdevila, Aura ; Carol, Marta ; Castera, Laurent ; Cervera, Marta ; Cucchietti, Fernando ; de Fuentes, Anna ; de Knegt, Rob ; Detlefsen, Sonke ; Diaz, Alba ; Bande, José Diéguez ; Esnault, Vanessa ; Fabrellas, Núria ; Falco, Josep lluis ; Fernández, Rosa ; Fournier, Celine ; Fuentes, Matilde ; Galle, Peter ; García, Edgar ; García-Retortillo, Montserrat ; Garrido, Esther ; Ginès, Pere ; Medina, Rosa Gordillo ; Gratacós- Gines, Jordi ; Graupera, Isabel ; Grgurevic, Ivica ; Guha, Indra Neil ; Guix, Eva ; Harris, Rebecca ; Boluda, Elena Hernández ; Hernández-Ibañez, Rosario ; Hoyo, Jordi ; Ikram, Arfan ; Incicco, Simone ; Israelsen, Mads ; Juan, Marta ; Juanola, Adria ; Kaiser, Ralf ; Kamath, Patrick S. ; Karlsen, Tom H. ; Kjærgaard, Maria ; de Koning, Harry J. ; Korenjak, Marko ; Krag, Aleksander ; Hansen, Johanne Kragh ; Krawczyk, Marcin ; Lambert, Irina ; Lammert, Frank ; Laboulaye, Philippe ; Sørensen, Simon Langkjær ; Laserna- Jiménez, Cristina ; Pi, Sonia Lazaro ; Ledain, Elsa ; Levy, Vincent ; Londoño, Vanessa ; Loyer, Guirec ; Llorca, Anne ; Ma, Ann T. ; Madir, Anita ; Manns, Michael ; Marshall, Denise ; Martí, M. Lluïsa ; Martínez, Sara ; Sala, Ricard Martínez ; Font, Roser Masa ; Jensen, Jane Møller ; Morillas, Rosa M. ; Muñoz, Laura ; Nadal, Ruth ; Napoleone, Laura ; Navarrete, J. M. ; Newsome, Phillip N. ; Nielsen, Vibeke ; Pérez, Martina ; Pulido, Juan Manuel Pericas ; Piano, Salvatore ; Pich, Judit ; Escobet, Judit Presas ; Pose, Elisa ; Lindvig, Katrine Prier ; Reichert, Matthias ; Riba, Carlota ; Roulot, Dominique ; Rubio, Ana Belén ; Sánchez- Morata, Maria ; Schattenberg, Jörn ; Serra- Burriel, Feliu ; Serra-Burriel, Miquel ; Just, Louise Skovborg ; Sonneveld, Milan ; Soria, Anna ; Stern, Christiane ; Such, Patricia ; Thiele, Maja ; Toran, Pere ; Torrejón, Antoni ; Tonon, Marta ; Tsochatzis, Emmanuel A. ; van Kleef, Laurens ; van Wijngaarden, Paulien ; Velázquez, Vanessa ; Viu, Ana ; Weber, Susanne Nicole ; Wildsmith, Tracey ; for the LiverScreen Consortium investigators

Kolaboracija
LiverScreen Consortium Investigators

Izvornik
BMC Public Health (1471-2458) 22 (2022), 1; 1385-1385

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chronic liver disease ; Cirrhosis ; Liver fibrosis ; NAFLD ; NASH ; Screening ; Vibration-controlled transient elastography.

Sažetak
Background: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. Methods: This study aims to include 30, 000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration- controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost- effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. Discussion: This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinička bolnica "Dubrava"

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

(LiverScreen Consortium Investigators) Graupera, Isabel; Thiele, Maja; Ma, Ann T.; Serra-Burriel, Miquel; Pich, Judit; Fabrellas, Núria; Caballeria, Llorenç; de Knegt, Robert J.; Grgurevic, Ivica; Reichert, Mathias et al.
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries // BMC Public Health, 22 (2022), 1; 1385-1385 doi:10.1186/s12889-022-13724-6 (međunarodna recenzija, članak, znanstveni)
(LiverScreen Consortium Investigators) (LiverScreen Consortium Investigators) Graupera, I., Thiele, M., Ma, A., Serra-Burriel, M., Pich, J., Fabrellas, N., Caballeria, L., de Knegt, R., Grgurevic, I. & Reichert, M. (2022) LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries. BMC Public Health, 22 (1), 1385-1385 doi:10.1186/s12889-022-13724-6.
@article{article, author = {Graupera, Isabel and Thiele, Maja and Ma, Ann T. and Serra-Burriel, Miquel and Pich, Judit and Fabrellas, N\'{u}ria and Caballeria, Lloren\c{c} and de Knegt, Robert J. and Grgurevic, Ivica and Reichert, Mathias and Roulot, Dominique and Schattenberg, J\"{o}rn M. and Pericas, Juan M. and Angeli, Paolo and Tsochatzis, Emmanuel A. and Guha, Indra Neil and Garcia-Retortillo, Montserrat and Morillas, Rosa M. and Hern\'{a}ndez, Rosario and Hoyo, Jordi and Fuentes, Matilde and Madir, Anita and Juanola, Adri\`{a} and Soria, Anna and Juan, Marta and Carol, Marta and Diaz, Alba and Detlefsen, S\"{o}nke and Toran, Pere and Fournier, C\'{e}line and Llorca, Anne and Newsome, Phillip N. and Manns, Michael and de Koning, Harry J. and Serra- Burriel, Feliu and Cucchietti, Fernando and Arslanow, Anita and Korenjak, Marko and van Kleef, Laurens and Falc\'{o}, Josep Lluis and Kamath, Patrick S. and Karlsen, Tom H. and Castera, Laurent and Lammert, Frank and Krag, Aleksander and Gin\`{e}s, Pere and Alvarez, Marif\'{e} and Andersen, Peter and Angeli, Paolo and Ard\`{e}vol, Alba and Arslanow, Anita and Beggiato, Luca and Abdesselam, Zahia Ben and Bennett, Lucy and Boutouria, Bajiha and Brocca, Alessandra and Broquetas, M. Teresa and Caballeria, Llorenc and Calvino, Valeria and Camacho, Judith and Capdevila, Aura and Carol, Marta and Castera, Laurent and Cervera, Marta and Cucchietti, Fernando and de Fuentes, Anna and de Knegt, Rob and Detlefsen, Sonke and Diaz, Alba and Bande, Jos\'{e} Di\'{e}guez and Esnault, Vanessa and Fabrellas, N\'{u}ria and Falco, Josep lluis and Fern\'{a}ndez, Rosa and Fournier, Celine and Fuentes, Matilde and Galle, Peter and Garc\'{\i}a, Edgar and Garc\'{\i}a-Retortillo, Montserrat and Garrido, Esther and Gin\`{e}s, Pere and Medina, Rosa Gordillo and Gratac\'{o}s- Gines, Jordi and Graupera, Isabel and Grgurevic, Ivica and Guha, Indra Neil and Guix, Eva and Harris, Rebecca and Boluda, Elena Hern\'{a}ndez and Hern\'{a}ndez-Iba\~{n}ez, Rosario and Hoyo, Jordi and Ikram, Arfan and Incicco, Simone and Israelsen, Mads and Juan, Marta and Juanola, Adria and Kaiser, Ralf and Kamath, Patrick S. and Karlsen, Tom H. and Kj\aergaard, Maria and de Koning, Harry J. and Korenjak, Marko and Krag, Aleksander and Hansen, Johanne Kragh and Krawczyk, Marcin and Lambert, Irina and Lammert, Frank and Laboulaye, Philippe and S\orensen, Simon Langkj\aer and Laserna- Jim\'{e}nez, Cristina and Pi, Sonia Lazaro and Ledain, Elsa and Levy, Vincent and Londo\~{n}o, Vanessa and Loyer, Guirec and Llorca, Anne and Ma, Ann T. and Madir, Anita and Manns, Michael and Marshall, Denise and Mart\'{\i}, M. Llu\"{\i}sa and Mart\'{\i}nez, Sara and Sala, Ricard Mart\'{\i}nez and Font, Roser Masa and Jensen, Jane M\oller and Morillas, Rosa M. and Mu\~{n}oz, Laura and Nadal, Ruth and Napoleone, Laura and Navarrete, J. M. and Newsome, Phillip N. and Nielsen, Vibeke and P\'{e}rez, Martina and Pulido, Juan Manuel Pericas and Piano, Salvatore and Pich, Judit and Escobet, Judit Presas and Pose, Elisa and Lindvig, Katrine Prier and Reichert, Matthias and Riba, Carlota and Roulot, Dominique and Rubio, Ana Bel\'{e}n and S\'{a}nchez- Morata, Maria and Schattenberg, J\"{o}rn and Serra- Burriel, Feliu and Serra-Burriel, Miquel and Just, Louise Skovborg and Sonneveld, Milan and Soria, Anna and Stern, Christiane and Such, Patricia and Thiele, Maja and Toran, Pere and Torrej\'{o}n, Antoni and Tonon, Marta and Tsochatzis, Emmanuel A. and van Kleef, Laurens and van Wijngaarden, Paulien and Vel\'{a}zquez, Vanessa and Viu, Ana and Weber, Susanne Nicole and Wildsmith, Tracey}, year = {2022}, pages = {1385-1385}, DOI = {10.1186/s12889-022-13724-6}, keywords = {Chronic liver disease, Cirrhosis, Liver fibrosis, NAFLD, NASH, Screening, Vibration-controlled transient elastography.}, journal = {BMC Public Health}, doi = {10.1186/s12889-022-13724-6}, volume = {22}, number = {1}, issn = {1471-2458}, title = {LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries}, keyword = {Chronic liver disease, Cirrhosis, Liver fibrosis, NAFLD, NASH, Screening, Vibration-controlled transient elastography.} }
@article{article, author = {Graupera, Isabel and Thiele, Maja and Ma, Ann T. and Serra-Burriel, Miquel and Pich, Judit and Fabrellas, N\'{u}ria and Caballeria, Lloren\c{c} and de Knegt, Robert J. and Grgurevic, Ivica and Reichert, Mathias and Roulot, Dominique and Schattenberg, J\"{o}rn M. and Pericas, Juan M. and Angeli, Paolo and Tsochatzis, Emmanuel A. and Guha, Indra Neil and Garcia-Retortillo, Montserrat and Morillas, Rosa M. and Hern\'{a}ndez, Rosario and Hoyo, Jordi and Fuentes, Matilde and Madir, Anita and Juanola, Adri\`{a} and Soria, Anna and Juan, Marta and Carol, Marta and Diaz, Alba and Detlefsen, S\"{o}nke and Toran, Pere and Fournier, C\'{e}line and Llorca, Anne and Newsome, Phillip N. and Manns, Michael and de Koning, Harry J. and Serra- Burriel, Feliu and Cucchietti, Fernando and Arslanow, Anita and Korenjak, Marko and van Kleef, Laurens and Falc\'{o}, Josep Lluis and Kamath, Patrick S. and Karlsen, Tom H. and Castera, Laurent and Lammert, Frank and Krag, Aleksander and Gin\`{e}s, Pere and Alvarez, Marif\'{e} and Andersen, Peter and Angeli, Paolo and Ard\`{e}vol, Alba and Arslanow, Anita and Beggiato, Luca and Abdesselam, Zahia Ben and Bennett, Lucy and Boutouria, Bajiha and Brocca, Alessandra and Broquetas, M. Teresa and Caballeria, Llorenc and Calvino, Valeria and Camacho, Judith and Capdevila, Aura and Carol, Marta and Castera, Laurent and Cervera, Marta and Cucchietti, Fernando and de Fuentes, Anna and de Knegt, Rob and Detlefsen, Sonke and Diaz, Alba and Bande, Jos\'{e} Di\'{e}guez and Esnault, Vanessa and Fabrellas, N\'{u}ria and Falco, Josep lluis and Fern\'{a}ndez, Rosa and Fournier, Celine and Fuentes, Matilde and Galle, Peter and Garc\'{\i}a, Edgar and Garc\'{\i}a-Retortillo, Montserrat and Garrido, Esther and Gin\`{e}s, Pere and Medina, Rosa Gordillo and Gratac\'{o}s- Gines, Jordi and Graupera, Isabel and Grgurevic, Ivica and Guha, Indra Neil and Guix, Eva and Harris, Rebecca and Boluda, Elena Hern\'{a}ndez and Hern\'{a}ndez-Iba\~{n}ez, Rosario and Hoyo, Jordi and Ikram, Arfan and Incicco, Simone and Israelsen, Mads and Juan, Marta and Juanola, Adria and Kaiser, Ralf and Kamath, Patrick S. and Karlsen, Tom H. and Kj\aergaard, Maria and de Koning, Harry J. and Korenjak, Marko and Krag, Aleksander and Hansen, Johanne Kragh and Krawczyk, Marcin and Lambert, Irina and Lammert, Frank and Laboulaye, Philippe and S\orensen, Simon Langkj\aer and Laserna- Jim\'{e}nez, Cristina and Pi, Sonia Lazaro and Ledain, Elsa and Levy, Vincent and Londo\~{n}o, Vanessa and Loyer, Guirec and Llorca, Anne and Ma, Ann T. and Madir, Anita and Manns, Michael and Marshall, Denise and Mart\'{\i}, M. Llu\"{\i}sa and Mart\'{\i}nez, Sara and Sala, Ricard Mart\'{\i}nez and Font, Roser Masa and Jensen, Jane M\oller and Morillas, Rosa M. and Mu\~{n}oz, Laura and Nadal, Ruth and Napoleone, Laura and Navarrete, J. M. and Newsome, Phillip N. and Nielsen, Vibeke and P\'{e}rez, Martina and Pulido, Juan Manuel Pericas and Piano, Salvatore and Pich, Judit and Escobet, Judit Presas and Pose, Elisa and Lindvig, Katrine Prier and Reichert, Matthias and Riba, Carlota and Roulot, Dominique and Rubio, Ana Bel\'{e}n and S\'{a}nchez- Morata, Maria and Schattenberg, J\"{o}rn and Serra- Burriel, Feliu and Serra-Burriel, Miquel and Just, Louise Skovborg and Sonneveld, Milan and Soria, Anna and Stern, Christiane and Such, Patricia and Thiele, Maja and Toran, Pere and Torrej\'{o}n, Antoni and Tonon, Marta and Tsochatzis, Emmanuel A. and van Kleef, Laurens and van Wijngaarden, Paulien and Vel\'{a}zquez, Vanessa and Viu, Ana and Weber, Susanne Nicole and Wildsmith, Tracey}, year = {2022}, pages = {1385-1385}, DOI = {10.1186/s12889-022-13724-6}, keywords = {Chronic liver disease, Cirrhosis, Liver fibrosis, NAFLD, NASH, Screening, Vibration-controlled transient elastography.}, journal = {BMC Public Health}, doi = {10.1186/s12889-022-13724-6}, volume = {22}, number = {1}, issn = {1471-2458}, title = {LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries}, keyword = {Chronic liver disease, Cirrhosis, Liver fibrosis, NAFLD, NASH, Screening, Vibration-controlled transient elastography.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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