Naslov
Algoritam globalne karte ponavljanja (Global Repeat map – GRM algorithm) kao genomska tehnologija za identifikaciju periodičnosti višeg reda
(Global Repeat Map (GRM) algorithm as genomic technology for Higher Order Repeat identification)

Autori
Vlahović, Ines

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Central European Conference on Information and Intelligent Systems Proceedings / Vrček, Neven ; Guàrdia, Lourdes ; Grd, Petra - Varaždin : Fakultet organizacije i informatike Sveučilišta u Zagrebu, 2022, 65-85

Skup
33rd Central European Conference on Information and Intelligent Systems (CECIIS 2022)

Mjesto i datum
Dubrovnik, Hrvatska, 21.09.2022. - 23.09.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
genomi, periodišnosti višeg reda, tandemsko ponavljanje, karcinom, alfa sateliti, NGS, ljudski genom, Y kromosom, NBPF geni, molekularne baze podataka
(genomes, higher order repeat, tandem repeat, cancer, alpha satellites, NGS, human genome, Y chromosome, NBPF genes, molecular databases)

Sažetak
In recent years new technologies for DNA sequence widened research of the roles of tandem repeats in eukaryotes, especially ones that are located in centromere region in chromosomes because of their importance for chromosome segregation, microtubule attachment to kinetochores and, as recently showed, their role in some diseases such as cancers. For identification of tandem repeats and higher order repeats (HORs) we use Global Repeat Map (GRM) algorithm and AlphaSub (ASu) algorithm, developed at Department of Physics, Faculty of Science, University of Zagreb. Here we present some illustrative results obtained using this tool. Based on analysis of DNA sequences, we create a database including information on location, length and divergence for alpha satellite arrays and HORs in human, Neanderthal and chimpanzee genomes (at link http://genom.hazu.hr). We summarize analysis of alpha satellite HORs for human Y chromosome, as well as for some other HORs identified in human and other primates’ chromosome 1 with novel comparison of ~1.6 kb monomer units in them. We also show preliminary results of GRM analysis of three breast cancer exomes. In this respect, we emphasize a need for employing new sequencing methods to determine complete genome assemblies for identification of more precise HOR structures.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Interdisciplinarne prirodne znanosti, Računarstvo, Interdisciplinarne biotehničke znanosti, Informacijske i komunikacijske znanosti

Napomena
Rad je objavljen na hrvatskom i engleskom jeziku

POVEZANOST RADA