Naslov
Serum biochemical changes associated with cystic ovarian degeneration in pigs after atrazine treatment

Autori
Gojmerac, Tihomira ; Kartal, Božica, Ćurić, Stipica ; Žurić, Marijan ; Stjepan, Kušević ; Cvetnić, Željko

Izvornik
Toxicology letters (0378-4274) 85 (1996), 1; 9-15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
s-Trazine herbicides ; atrazine ; toxicology ; reproduction

Sažetak
Biochemical and histopathological parameters of the ovarian function were observed to asses the toxic effect of low dose of atrazin, an s-triazine herbicide, in female pigs (gilts) undergoing intensive breeding. Female pigs (cross-bred between Swedish and German landrace) received 2 mg atrazine kg-1 body wt. in feed daily during 19 days of the oestrus cycle. The last treatment day correspondent to day -3 of the on set of the next expected oestrus. Blood samples were collected 3 times daily at 3-h intervals on the first 5 post- treatment days. Serum 17B -oestradiol (17B-E) and progesterone (P) concentrations were determined. A significantly higher (P< 0.05 and P< 0.001, respectively) serum P concentration and significantly lower (P< 0.01 and 0.001, respectively) seru, m 17b-E concentration was recorded 48and 24 h before the onset of the next expected oestrus in atrazine-treated pigs, as compared to intact pigs. The onset of next expected oestrus failed to occur, but no other adverse clinical reactions associated with the treatment were recorded. Histopatological examination, of the ovaries of treted pigs indicated multiple ovarian follicular cysts and persistence of corpus luteum. Biochemmical and histopathological findings showed that subacute exposure of female pigs to low dose of atrazine their oestrus cycle.

Izvorni jezik
Engleski

Znanstvena područja
Šumarstvo

POVEZANOST RADA