Naslov
Incidence and survival of patients with primary brain tumors in sunny Dalmatia

Autori
Marčić, Marino, Silić, Slobodan ; Romac, Rinaldo ; Vučina, Dijana ; Begić, Vesna ; Veselica, Gorana ; Titlić, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Konres neurologa BiH 2016. / - , 2016, 78-79

Skup
Kongres neurologa Bosne i Hercegovine

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 10.10.2016. - 15.10.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
brain tumor, Dalmatia

Sažetak
Brain tumors account for 1.4% of all cancers and 2.4% of all cancer-related deaths. Brain tumors seemed to have increased in incidence over the past 30 years, but the rise probably results from use of new neuroimaging techniques. Treatments have not improved prognosis for rapidly fatal brain tumors. Established brain tumor risk factors (exposure to ionizing radiation, rare mutations of penetrant genes, and familial history) explain only a small proportion of brain tumors, and only one of these potentially is modifiable. Genetic and environmental characteristics likely play a role in familial aggregation of malignant glioma and these factors are not identified. Sunlight is essential for the production of vitamin D in the body. Evidence exists to suggest that vitamin D metabolites may have a role in tumor growth suppression. We have analyzed 256 pateints with malignant gliomas during two years (2013.and 2014.). We analyzed incidence of tumors through out the year, role of season of diagnosis and sunlight exposure and cancer survival. There is no seasonality of incidence of brain cancers, but we found evidence of substantial seasonality in cancer survival, with patients who get their diagnosis in summer and autumn associated with improved survival compared with that in winter.Cumulative sunlight exposure in the months preceding diagnosis was also a predictor of subsequent survival, although season of diagnosis was a stronger predictor than cumulative sunlight exposure. Our results add to a growing body of evidence that vitamin D metabolites play an important role in cancer survival, especialy in sunny places like Dalmatian region. Further studies needs to be done in this field of intrest.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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