Naslov
Evaluation of antimicrobial photodynamic activities of 5-aminolevulinic acid derivatives

Autori
Sajjad, Faiza ; Sun, Ning-Ning ; Chen, Ting ; Yan, Yi-Jia ; Margetić, Davor ; Chen, Zhi-Long

Izvornik
Photodermatology photoimmunology & photomedicine (0905-4383) 37 (2021), 4; 296-305

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-ALA derivatives ; antimicrobial photodynamic therapy ; Escherichia coli ; photosensitizers ; Staphylococcus aureus

Sažetak
Background: Antibiotic resistance is increasing day by day, thereby increase the chances of more infections by resistant bacteria. In this situation, antimicrobial photodynamic therapy (aPDT) is gaining more attraction. Objective: To evaluate the antimicrobial effect of ALA derivatives using photodynamic therapy. Materials and methods: In this study, we evaluated the aPDT effect of different derivatives of 5-ALA. In vivo and in vitro studies were performed to measure the antimicrobial activity. Different light doses and different concentrations of drugs were used to test anti-bacterial effect of drugs as well as to detect any physiological changes in animal model after the treatment. Results: In vivo studies revealed that ALA-methyl ester, ALA-hexyl ester, and ALA- 13A are potent photosensitizers. In vitro studies involved wound healing rate, body weight, and dietary intake were evaluated, and results showed that ALA, ALA-methyl ester, ALA-hexyl ester, and ALA-13A had good anti- bacterial effects, fast healing rate, and no effect on other physical parameters. Conclusion: Photodynamic therapy is increasingly used to treat different types of skin infections caused by bacterial strains. Our studies revealed that ALA-methyl ester, ALA-hexyl ester, and ALA-13A are promising photosensitizers for photodynamic therapy to inhibit the growth of resistant bacterial strains.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA