Naslov
Akutna promijelocitna leukemija M3- citomorfološke, citogenetske i molekularne varijante
(Acute promyelocytic leukemia M3- cytomorphologic, cytogenetic and molecular variants)

Autori
Burazer, Brankica ; Zadro, Renata ; Sučić, Mirna ; Labar, Boris ; Aurer, Igor ; Mrsić, Sanja ; Boban, Dubravka ; Batinić, Drago ; Stavljenić, Ana ; et al.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine / - , 1999, 216-216

Skup
IFCC-WorldLab´99

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Akutna promijelocitna leukemija M3, varijante
(Acute promyelocytic leukemia M3, variants)

Sažetak
Acute promyelocitic leukemia M3 is AML subtype characterized by proliferation of malignant promyelocytes with mature myeloid immunophenotype and atypical reciprocal traslocation involving chromosome 15 and 17 (t(15 ; 17)(q22 ; q11)) resulting in the fusion of retinoic acid receptor alpha (RAR alpha) on chromosome 17 and the putative factor PML. There are three M3 morphologic variants: typical hypergranular form, hypogranular and basophilic variant. However, some of patients have not specific translocation, or they have other cytogenetic abnormalities beside or without characteristic ones. The aim of the study was to compare morphologic, immunologic, cytogenetic and molecular characteristic of blasts in 15 patients with M3 treated in Clinical Hospital Zagreb, Zagreb, Croatia. In major M3 patients (13) blasts had typical hypergranular appearance with mature myeloid immunophenotype (HLD-DR-, CD13+, CD33+). Typical translocation t(15 ; 17)(q22 ; q11) was detected by cytogenetic analysis in 5 M3 patients but PML/RARalpha was positive in 11 out of 14 patients with RT-PCR. In one patient t(17 ; 17) was found, in 2 patients with +8 one patient had also add (7)(q22) and -7. Patients with complete remission (13) became PML/RARalpha negative. Four of them reverted to PCR positivity and relapsed within 3 months.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA