Naslov
Dexmedetomidine as an adjuvant to levobupivacaine for spinal anesthesia in elderly patients: a prospective, randomized, double- blinded study

Autori
Bodulica, Bruna ; Ozegic, Ognjen ; Pazur, Iva ; Lijovic, Lada ; Radocaj, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Clin Croat 2022 ; 61(Suppl 1):167-168 / - , 2022, 167-168

Skup
8 međunarodni stručno-znanstveni skup: Zaštita na radu i zaštita zdravlja

Mjesto i datum
Zagreb, Hrvatska, 02.09.2022. - 03.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Dexmedetomidine

Sažetak
Background: The main goal of this study was to compare opioids with dexmedetomidine as adjuvant to spinal anesthesia, especially their effect on hemodynamic stability in elderly patients. Hypothesis of this study is that dexmedetomidine offers equal quality of spial anesthesia with lower incidence of side effects. Methods: Spinal anesthesia was performed on thirty ASA grade II and III geriatric patients undergoing hip surgery. Noninvasive blood pressure, heart rate and spo2 were noted every 5 minutes. Patients were randomly assigned into two groups: control group (n=15) received levobupivacaine by body height normogram with 2.5 mcg (0.5 ml) of sufentanil, while subject group (n=15) received levobupivacaine by body height nomogram with 5 mcg of dexmedetomidine. Groups were compared by hemodynamic parameters, use of vasopressors and side effects: bradycardia, hypotension, respiratory depression. Results: Baseline patients characteristics were comparable in both groups. Analysis of hemodynamic data showed that incidence of hypotension was not significantly different between groups. Vasopressors were used in 46.7% of cases in control group and 40.0% in subject group, without statistically significant difference. There was no statistically significant difference between groups in any side-effects reported. Conclusions: Results of this study show that dexmedetomidine is a safe adjuvant to local anesthetics in elderly patients receiving spinal anesthesia. There is no significant difference between opioids and dexmedetomidine in both hemodynamic stability and the incidence of side- effects.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti), Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA