Pregled bibliografske jedinice broj: 1213151
The occurrence of sacroilitis in HLA-B*35 positive patients with unfdifferentiated spondyloarthritis
The occurrence of sacroilitis in HLA-B*35 positive patients with unfdifferentiated spondyloarthritis // HLA Immunne response genetics Special Issue: Abstracts for the Joint 35th European Immunogenetics and Histocompatibility Conference Amsterdam, the Netherlands, May 17–20, 2022
Amsterdam, Nizozemska, 2022. str. 521-521 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1213151 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The occurrence of sacroilitis in HLA-B*35 positive
patients with
unfdifferentiated spondyloarthritis
Autori
Tarabene, Matea ; Šošo, Daniela ; Čečuk-Jeličić, Esma ; Jaman, Sonja
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
HLA Immunne response genetics Special Issue: Abstracts for the Joint 35th European Immunogenetics and Histocompatibility Conference Amsterdam, the Netherlands, May 17–20, 2022
/ - , 2022, 521-521
Skup
36th European Immunogenetics and Histocompatibility Conference
Mjesto i datum
Amsterdam, Nizozemska, 17.05.2022. - 20.05.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
undifferentiated spondyloarthritis, sacroilitis, HLA-B*35, bone marrow edema, peripheral joint synovitis
Sažetak
Undifferentiated spondyloarthritis (un-SpA) is a subgroup of spondyloarthritis (SpA) – chronic rheumatic diseases that affects spine and peripheral joints. The aim of our study was to assess whether the presence of HLA-B*35 had any clinical correlation with sacroilitis in patients with a preliminary diagnosis of un-SpA. HLA typing of 110 patients with excludedaxial spondyloarthritis and HLA-B*27 positivity showed 2x higher HLA-B*35 allele frequency when compared to group of 100 control group samples (32% vs 15%), thereby indicating significant association between HLA-B*35 allele and un-SpA diagnosis. Patients were also tested using MRI, ultrasound and a full blood panel test that ensured at least one of the SpA clinical requirement was met. HLA-B*35 positivity included a 6 times greater chance of identifying bone marrow edema on sacroiliac joints on MRI (OR 6, 95% CI 1.3–27, p=0.021) in conjunction with a 4.7 times greater chance of finding an elevated CRP value (OR 4.7, 95% CI 1–11.9, p=0.047) and 5 times greater chance of finding peripheral joint synovitis (OR 5, 95% CI 1.75–14.3, p=0.003).These results indicate there is a clinical significance of a HLA-B*35 positivity in patients with un-SpA, but further investigations on larger number of patients are needed to confirm the results our research.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
