Naslov
Antioxidant and cosmeceutical activity of Plantago major extracts

Autori
Jakupović, Lejsa ; Marijan, Marijan ; Sladić, Anđela ; Ninić, Adriana ; Zovko Končić, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
“70th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”

Mjesto i datum
Solun, Grčka, 28.08.2022. - 31.08.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
plantago major, enzyme activity, solvents, hyaluronidase, collagenase, elastase

Sažetak
Plantago major L. (Plantaginaceae), known as great platain, is a widespread used medicinal plant. The aerial parts contain numerous active compounds including flavonoids, polysaccharides, terpenoids, lipids, iridoid glycosides and caffeic acid derivates (1). P. major contains verbascosid, a derivate from phenolic acid, and aucubin, an iridoid with numerous beneficial skin-related properties such as wound healing and anti- inflammatory effects (2). In this work, P. major extracts were prepared with biocompatible solvents, such as water, glycerol, and lactic acid by using ultrasound bath extraction for 20 minutes. The prepared extracts (OPT-TP, OPT-TPA, OPT-VER and OPT-AUC) were rich in total polyphenol content (2059.66 ± 139.34 μg/mL, 1846.39 ± 13.44 μg/mL, 1879.15 ± 39.81 μg/mL, 1747.77 ± 44.03 μg/mL, respectively). The antioxidant effects were tested using DPPH radical scavenging activity and reducing power. The activity related to inhibitory effects of skin-related enzymes elastase, hyaluronidase, and lipoxygenase, were tested. All the prepared extracts displayed strong radical scavenging and reducing properties. OPT-AUC, extract with the highest concentration of aucubin (955.44 μg/mL) showed the best anti-elastase (69.34 ± 4.29 μg/mL) and lipoxygenase (50.43 ± 1.85 μg/mL) activity, On the other hand OPT-TP, extract with the highest polyphenol content showed the best anti-hyaluronidase (16.96 ± 0.51 μg/mL) activity. In addition to excellent antioxidant and enzyme-inhibiting properties, the extracts have an additional advantage of being prepared using skin- friendly solvents which can make them ideal ingredients for cosmetic products.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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