Naslov
Outcome of patients with advanced laryngeal carcinoma - a multicentric retrospective study

Autori
Marijić Blažen ; Janik Stefan ; Grasl Stefan ; Grasl Matthäus Christoph ; Tudor Filip ; Erovic Boban M.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Libri Oncologici : Croatian Journal of Oncology, Vol. 50 No. Supplement 1, 2022. / Vrdoljak, Eduard ; Jazvić, Marijana - Zagreb : University Hospital for Tumors, Zagreb, Croatia, 2022, 129-130

Skup
15. hrvatski onkološki kongres (HOK 2022)

Mjesto i datum
Opatija, Hrvatska, 31.03.2022. - 03.04.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
laryngeal cancer, larynx, radiotherapy, outcomes, head and neck

Sažetak
Background: The purpose of this study was to assess the oncological and long-term functional outcomes of patients who underwent total laryngectomy (TL) or primary radiotherapy (RT) for advanced laryngeal carcinoma. Methods: Of the 190 patients, 146 had TL without flap reconstruction and 44 had primary RT. Overall (OS) and disease- free survival (DFS), and functional outcome according to the Vienna classification system were evaluated and analyzed. Results: According to the Vienna classification system, all laryngectomy patients were classified as IA patients. Post- surgical complications occurred in 33 (22.6 %) of the cases, with 18 (12.3 %) experiencing pharyngocutaneous fistulae and 11 (5.8 %) experiencing stenosis. Voice rehabilitation was achieved in 132 (90.4 %) of 146 patients using voice prosthesis insertion (n=113, 77.4 %), esophageal speech (n=14, 9.6 %), and electrolarynx (n=5, 3.4 %). Patients who were primarily treated with RT (class IR) had less satisfactory outcomes. In particular, 56.8 % (n=25), 20.5 % (n=9), and 22.7 %(n=10) of patients achieved total, partial, or no oral food intake, respectively. Voice rehabilitation was not required in any of the RT patients. Altogether, oral nutrition was established in 93.7% (n=178) of 190 cases (84.7%, n=161 completely, and 8.9%, n=17 partially) with a poorer outcome in patients treated with RT (P<.001). At the end of follow-up, DFS and OS were significantly better for patients who were treated with primary surgery when compared to the RT group (P <.001 ; P=.002, retrospectively). Conclusion: When compared to primary RT, surgical treatment of advanced laryngeal tumors without pharyngeal involvement has a significantly better oncological and functional outcome, and adequate voice rehabilitation can be achieved in the vast majority of cases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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