Naslov
Experience with comprehensive pharmacogenomic multi-gene panel in clinical practice: a retrospective single-center study
(Experience with comprehensive pharmacogenomic multi-gene panel in clinical practice: a retrospective single-center study)

Autori
Matišić, Vid ; Brlek, Petar ; Molnar, Vilim ; Pavelić, Eduard ; Čemerin, Martin ; Vrdoljak, Kristijan ; Skelin, Andrea ; Erceg, Damir ; Moravek, Davor ; Ivkošić, Ivana Erceg ; Primorac, Dragan

Izvornik
Croatian Medical Journal (0353-9504) 63 (2022), 3; 257-264

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pharmacogenomic, drug-gene pairs, genotype-based prescribing
(pharmacogenomic, drug-gene pairs, genotype-based prescribin)

Sažetak
Aim To assess the prevalence of actionable pharmacogenetic interventions in patients who underwent pharmacogenetic testing with a multi- gene panel. Methods We retrospectively reviewed single-center electronic health records. A total of 319 patients were enrolled who underwent pharmacogenomic testing with the RightMed test panel using TaqMan quantitative real-time PCR method and copy number variation analysis to determine the SNPs in the 27 target genes. Results Actionable drug-gene pairs were found in 235 (73.7%) patients. Relevant guidelines on genotype- based prescribing were available for 133 (56.7%) patients at the time of testing. Based on the patients' genotype, 139 (43.6%) patients were using at least one drug with significant pharmacogenetic interactions. Conclusion Two out of three patients had at least one drug- gene pair in their therapy. Further studies should assess the clinical effectiveness of integrating pharmacogenomic data into patients' electronic health records.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA