Naslov
IMPLEMENTATION OF CONTINUOUS FLOW PROCESS FOR LITHIATION REACTION IN API SYNTHESIS

Autori
Zrinka Mastelić Samardžić, Vitomir Vušak, Moris Mihovilović, Aida Omerbašić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Conference 18th Ružička Days - Book of Abstracts / Jukić, Ante - Zagreb : Osijek : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2020, 77-77

ISBN
978-953-6894-75-8

Skup
18. Ružičkini dani "Danas znanost - sutra industrija"

Mjesto i datum
Vukovar, Hrvatska, 16.09.2020. - 19.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
flow chemistry ; continuous process ; lithiation

Sažetak
Although the advantages of organolithium compounds are well known, the same are still avoided in industrial world as dangerous and difficult to handle in multi-kg scale. Lithiation reactions in a batch mode are typically conducted under cryogenic temperatures (-78 to -40 ˚C) to minimize the side reactions arising from the highly reactive organlithium intermediates [1]. Challenges of safe handling highly reactive chemicals and a highly energetic reactions in scaled-up operations is a major disadvantage of such batch processes [1]. This work represents overcoming these safety and technical issues by implementation of continuous flow process for lithiation reaction which is part of process for synthesis of one active pharmaceutical ingredient. Through very extensive development, many innovative solutions were involved in flow process to overcome technical difficulties. Final results are hundreds of grams of obtained product produced under safe conditions in a short time, at moderate temperatures and in cheap and flexible equipment. The aim of this work is to share the most interesting details of process and to show all potentials and beauty of flow chemistry.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo

POVEZANOST RADA