Pregled bibliografske jedinice broj: 1211271
Development of continuous crystallization process using single stage mixed‐suspension, mixed product removal crystallizer (MSMPR)
Development of continuous crystallization process using single stage mixed‐suspension, mixed product removal crystallizer (MSMPR) // 26. Croatian Meeting of Chemists and Chemical Engineers, Book of Abstracts / Nives Galić, Marko Rogošić (ur.).
Zagreb, 2019. str. 129-129 (poster, nije recenziran, sažetak, znanstveni)
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Naslov
Development of continuous crystallization process
using single stage mixed‐suspension, mixed product
removal crystallizer (MSMPR)
Autori
Mihaela Tuksar, Moris Mihovilović, Ivica Grebenar, Dražen Čavužić
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
26. Croatian Meeting of Chemists and Chemical Engineers, Book of Abstracts
/ Nives Galić, Marko Rogošić - Zagreb, 2019, 129-129
Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog
Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Kontinuirana kristalizacija, MSMPR
(Continuous crystallization, MSMPR)
Sažetak
Transition from batch crystallization to continuous crystallization gains more and more attention in pharmaceutical production [1, 2]. Main disadvantage of batch crystallization, product variability, could be reduced by continuous crystallization due its stable conditions and operation at steady state. For pharmaceutical application, mixed‐suspension, mixed product removal (MSMPR) crystallizers in single or multiple stage is the mostly used approach [3, 4]. It represents simple, yet efficient way to crystallize the desired product in a continuously fed crystallizer and continuously removed output of the suspension on the isolation equipment. When coupled with various in line methods for monitoring (PAT), continuous crystallization can be fully controlled, robust and commercially scaled up. In this study, a batch production procedure of an API is successfully transferred to a lab scale antisolvent crystallization using a single stage MSMPR system. Additional work was done concerning in line control of the crystallization and achievement of steady state. FBRM and UV measurements were conducted for better understanding of continuous crystallization. We will demonstrate a very simple but effective setup of the single stage MSMPR constructed from already available equipment in the lab.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kemijsko inženjerstvo
