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Pregled bibliografske jedinice broj: 1210696

Molecular and cellular evolution of the primate dorsolateral prefrontal cortex

Ma, S; Škarica, Mario; Li, Q; Xu, C; Risgaard, R D.; Tebbenkamp, A T. N.; Mato-Blanco, X; Kovner, R; Krsnik, Željka; de Martin, X et al.
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex // Science, 377 (2022), 6614; eabo7257, 1 doi:10.1126/science.abo7257 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1210696 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex

Autori
Ma, S ; Škarica, Mario ; Li, Q ; Xu, C ; Risgaard, R D. ; Tebbenkamp, A T. N. ; Mato-Blanco, X ; Kovner, R ; Krsnik, Željka ; de Martin, X ; Luria, V ; Martí-Pérez, X ; Liang, D ; Karger, A ; Schmidt, D K. ; Gomez-Sanchez, Z ; Qi, C ; Gobeske, K T. ; Pochareddy, S ; Debnath, A ; Hottman, C J. ; Spurrier, J ; Teo, L ; Boghdadi, A G. ; Homman-Ludiye, J ; Ely, J J. ; Daadi, E W. ; Mi, D ; Daadi, M ; Marín, O ; Hof, P R. ; Rasin, MR ; Bourne, J ; Sherwood, CC. ; Santpere, G ; Girgenti, M J. ; Strittmatter, S M. ; Sousa, A, M. M. ; Šestan, Nenad

Izvornik
Science (0036-8075) 377 (2022), 6614; Eabo7257, 1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PFC, FOXP2

Sažetak
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600, 000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several that exist only in a subset of species as well as substantial species-specific molecular differences across homologous neuronal, glial, and non-neural subtypes. The latter are exemplified by human- specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons. The above molecular differences are also illustrated by expression of the neuropsychiatric risk gene FOXP2, which is human- specific in microglia and primate-specific in layer 4 granular neurons. We generated a comprehensive survey of the dlPFC cellular repertoire and its shared and divergent features in anthropoid primates.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Željka Krsnik (autor)

Avatar Url Mario Škarica (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Ma, S; Škarica, Mario; Li, Q; Xu, C; Risgaard, R D.; Tebbenkamp, A T. N.; Mato-Blanco, X; Kovner, R; Krsnik, Željka; de Martin, X et al.
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex // Science, 377 (2022), 6614; eabo7257, 1 doi:10.1126/science.abo7257 (međunarodna recenzija, članak, znanstveni)
Ma, S., Škarica, M., Li, Q., Xu, C., Risgaard, R., Tebbenkamp, A., Mato-Blanco, X., Kovner, R., Krsnik, Ž. & de Martin, X. (2022) Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science, 377 (6614), eabo7257, 1 doi:10.1126/science.abo7257.
@article{article, author = {Ma, S and \v{S}karica, Mario and Li, Q and Xu, C and Risgaard, R D. and Tebbenkamp, A T. N. and Mato-Blanco, X and Kovner, R and Krsnik, \v{Z}eljka and de Martin, X and Luria, V and Mart\'{\i}-P\'{e}rez, X and Liang, D and Karger, A and Schmidt, D K. and Gomez-Sanchez, Z and Qi, C and Gobeske, K T. and Pochareddy, S and Debnath, A and Hottman, C J. and Spurrier, J and Teo, L and Boghdadi, A G. and Homman-Ludiye, J and Ely, J J. and Daadi, E W. and Mi, D and Daadi, M and Mar\'{\i}n, O and Hof, P R. and Rasin, MR and Bourne, J and Sherwood, CC. and Santpere, G and Girgenti, M J. and Strittmatter, S M. and \v{S}estan, Nenad}, year = {2022}, pages = {1}, DOI = {10.1126/science.abo7257}, chapter = {eabo7257}, keywords = {PFC, FOXP2}, journal = {Science}, doi = {10.1126/science.abo7257}, volume = {377}, number = {6614}, issn = {0036-8075}, title = {Molecular and cellular evolution of the primate dorsolateral prefrontal cortex}, keyword = {PFC, FOXP2}, chapternumber = {eabo7257} }
@article{article, author = {Ma, S and \v{S}karica, Mario and Li, Q and Xu, C and Risgaard, R D. and Tebbenkamp, A T. N. and Mato-Blanco, X and Kovner, R and Krsnik, \v{Z}eljka and de Martin, X and Luria, V and Mart\'{\i}-P\'{e}rez, X and Liang, D and Karger, A and Schmidt, D K. and Gomez-Sanchez, Z and Qi, C and Gobeske, K T. and Pochareddy, S and Debnath, A and Hottman, C J. and Spurrier, J and Teo, L and Boghdadi, A G. and Homman-Ludiye, J and Ely, J J. and Daadi, E W. and Mi, D and Daadi, M and Mar\'{\i}n, O and Hof, P R. and Rasin, MR and Bourne, J and Sherwood, CC. and Santpere, G and Girgenti, M J. and Strittmatter, S M. and \v{S}estan, Nenad}, year = {2022}, pages = {1}, DOI = {10.1126/science.abo7257}, chapter = {eabo7257}, keywords = {PFC, FOXP2}, journal = {Science}, doi = {10.1126/science.abo7257}, volume = {377}, number = {6614}, issn = {0036-8075}, title = {Molecular and cellular evolution of the primate dorsolateral prefrontal cortex}, keyword = {PFC, FOXP2}, chapternumber = {eabo7257} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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