Pregled bibliografske jedinice broj: 121002
Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B
Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B // Tetrahedron: asymmetry, 14 (2003), -; 2725-2730 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 121002 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Kinetic Resolution of Diastereomeric Racemates of 7-Bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one by Immobilized CAL-B
Autori
Majerić-Elenkov, Maja ; Hameršak, Zdenko ; Šunjić, Vitomir
Izvornik
Tetrahedron: asymmetry (0957-4166) 14
(2003);
2725-2730
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Kinetic Resolution; Diastereomeric Racemates
Sažetak
Immobilized CAL-B catalyzed kinetic resolution of syn-7-bromo-3-(1`-hydroxy-ethyl)-1-methyl-5-(2`-pyridyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one syn-( )-2) and its anti-diastereomer ( )-3) are achieved with E-values over 200. Completely enantioselective acetylation of (1´R)-enantiomers in diastereomeric racemates with opposite configuration at the second stereogenic center C(3) occurs at substantially different rate (t1/2syn/t1/2anti ca 1/20). Conformational origins of enantioselection are discussed.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
