Naslov
RELATIONSHIP OF DYSLIPIDEMIA AND IMMUNOSUPRESSIVE THERAPY IN LIVER TRANSPLANT RECIPIENTS
(Atherosclerosis, lipids and lipoproteins)

Autori
Perkov, Sonja ; Flegar-Meštrić, Zlata ; Radeljak, Andrea ; Starčić, Jelena ; Višković Filipčić, Nataša ; Filipec Kanižaj, Tajana

Izvornik
Clinical Chemistry and Laboratory Medicine (CCLM) (1437-4331) 53 (2015), S1; S314-s314

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DYSLIPIDEMIA ; IMMUNOSUPRESSIVE THERAPY ; LIVER TRANSPLANT

Sažetak
BACKGROUND-AIM Dyslipidemia is a major risk factor for post-transplant cardiovascular morbidity in liver transplant recipients (LTRs).Our aim was to determine prevalence of lipids abnormalities in LTRs and to assess its relationship with theimmunosupressive therapies in the early posttransplantation period. METHODS 76 patients undergoing liver transplantation (LT) from 2013 to 2014 in the Merkur University Hospital, Zagreb, Croatia, a member of Eurotransplant, were included. They received cyclosporin (CSA) (n=43) or tacrolimus (TAC) therapy (n=33).Total cholesterol (TC), High-Density-Lipoprotein cholesterol (HDL-C), Low-Density-Lipoprotein cholesterol (LDL-C) andtriglycerides (TG) levels were evaluated at the 1st and 3rd months after LT. Serum TG and TC were measured byenzymatic PAP- method. HDL-C was measured with direct method based on selective inhibition of the non- HDLfractions, while LDL-C was determined indirectly. All methods used in this study are accredited according to ISO 15189. RESULTS The concentrations of TG, TC and LDL-C did not differ significantlly between CSA and TAC treated patients, whereasHDL-C were signifficantly lower in CSA groups after 1st ( P=0, 049) and after 3rd months (P=0, 009), respectivelly. InCSA groups level of HDL-C (P=0, 007), TC (P= 0, 019) and TG (P= 0, 020) significantlly decreased from 1st to 3rd months, whereas no difference in the level of LDL-C was observed over time. In TAC groups levels of HDL-C remained unchanged, whereas level of LDL-C (P=0, 015), TC (P= 0, 021) and TG (P= 0, 005) decrease over time. The presence of a least one typeof dyslipidemia was observed in 73, 7% our LTRs after 1st months. The increased levels of TG, TC, LDL-C or decreasedHDL-C were observed in 39, 5%, 36, 8%, 38, 1% and 31, 6%% respectively. Initially the prevalence of lipid abnormalitiesdid not differ beetwen two groups, but after 3rd months the prevalence of low HDL-C is significantlly higher in CSAvs. TAC groups (P=0, 017). CONCLUSION Our results showed that dyslipidemia as risk factor for posttransplant cardiovascular morbidity is common in LTRsmostly in patients treated with CSA in early posttransplantation period. These results suggest that LTRs should becarefully followed to prevent cardiovascular complication.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA