Naslov
Material Science and Structure Property Relationships in Research and Development of Drug based on Macrocycles rings

Autori
Meštrović, Ernest

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Macrocycles: synthesis, medicinal chemistry and biological activity / - , 2014, 1-1

Skup
The Macrocycles: synthesis, medicinal chemistry and biological activity

Mjesto i datum
Zagreb, Hrvatska, 28.04.2014. - 29.04.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
Materials Science ; pharmaceutical materials science ; product development

Sažetak
The field of Materials Science has most commonly been associated with the study of structural or functional materials for engineering and construction applications, such as metals, ceramics, glass, semiconductors and composites. Now this discipline put in the focus soft matter, including polymers, powders, and biomaterials. From another aspect, in the pharmaceutical science there is many changes and opportunity which can be solved by apply physical principles common in materials science to challenges in such areas as drug delivery, control of drug form, manufacture and processing of nanoscopic and microscopic particle systems, and the structure and properties of bulk powders and their assemblies (e.g., tablets) for use in pharmaceutical applications. The concept of Materials Science Tetrahedron (MST) which is common practice in research and development of advance material can be also apply to development of pharmaceutical product by concisely depicts the inter-dependent relationship among the structure, properties, performance, and processing of a drug. Similar to its role in traditional materials science, MST encompasses the development in the emerging field of pharmaceutical materials science and forms a scientific foundation to the design and development of new drug products. Examples are given to demonstrate the applicability of MST to both pharmaceutical research and product development. It is proposed that a systematic implementation of MST can expedite the transformation of pharmaceutical product development from an art to a science. Applying of MST concept on several macrocyclic compounds lead R&D activities in PLIVA starting from basic idea up to final drug product.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Farmacija

POVEZANOST RADA