Naslov
Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020

Autori
Naehrlich, Lutz ; Orenti, Annalisa ; Dunlevy, Fiona ; Kasmi, Irena ; Harutyunyan, Satenik ; Pfleger, Andreas ; Keegan, Svetlana ; Daneau, Géraldine ; Petrova, Guergana ; Tješić-Drinković, Duška ; Yiallouros, Panayiotis ; Bilkova, Alena ; Olesen, Hanne Vebert ; Burgel, Pierre-Régis ; Parulava, Tsitsino ; Diamantea, Filia ; Párniczky, Andrea ; McKone, Edward F ; Mei-Zahav, Meir ; Salvatore, Marco ; Colombo, Carla ; Aleksejeva, Elina ; Malakauskas, Kestutis ; Schlesser, Marc ; Fustik, Stojka ; Turcu, Oxana ; Zomer-van Ommen, Domenique ; Wathne, Anita Senstad ; Woźniacki, Łukasz ; Pereira, Luísa ; Pop, Liviu ; Kashirskaya, Nataliya ; Rodić, Milan ; Kayserova, Hana ; Krivecs, Uro ; Mondejar-Lopez, Pedro ; de Monestrol, Isabelle ; Dogru, Deniz ; Makukh, Halyna ; Cosgriff, Rebecca ; van Koningsbruggen- Rietschel, Silke ; Jung, Andreas

Kolaboracija
European Cystic Fibrosis COVID project group

Izvornik
Journal of cystic fibrosis (1569-1993) 20 (2021), 4; 566-577

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cystic fibrosis ; Covid-19 ; SARS-CoV-2 ; Europe ; incidence ; epidemiology

Sažetak
Background Viral infections can cause significant morbidity in cystic fibrosis (CF). The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could therefore have a serious impact on the health of people with CF (pwCF). Methods We used the 38-country European Cystic Fibrosis Society Patient Registry (ECFSPR) to collect case data about pwCF and SARS-CoV-2 infection. Results Up to 30 June 2020, 16 countries reported 130 SARS-CoV-2 cases in people with CF, yielding an incidence of 2.70/1000 pwCF. Incidence was higher in lung-transplanted patients (n=23) versus non- transplanted patients (n=107) (8.43 versus 2.36 cases/1000). Incidence was higher in pwCF versus the age-matched general population in the age groups <15, 15-24, and 25-49 years (p<0.001), with similar trends for pwCF with and without lung transplant. Compared to the general population, pwCF (regardless of transplantation status) had significantly higher rates of admission to hospital for all age groups with available data, and higher rates of intensive care, although not statistically significant. Most pwCF recovered (96.2%), however 5 died, of whom 3 were lung transplant recipients. The case fatality rate for pwCF (3.85%, 95% CI: 1.26-8.75) was non- significantly lower than that of the general population (7.46% ; p=0.133). Conclusions SARS- CoV-2 infection can result in severe illness and death for pwCF, even for younger patients and especially for lung transplant recipients. PwCF should continue to shield from infection and should be prioritized for vaccination.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
European Cystic Fibrosis COVID project group (Croatia):
Ivan Bambir, Andrea Dugac Vukić

POVEZANOST RADA