Pregled bibliografske jedinice broj: 1208374
Multiple alignment method for identification of catalytic microenvironments in enzymes
Multiple alignment method for identification of catalytic microenvironments in enzymes // European Rosettacon 2022
Varšava, Poljska, 2022. (poster, međunarodna recenzija, ostalo, znanstveni)
CROSBI ID: 1208374 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Multiple alignment method for identification of
catalytic microenvironments in enzymes
Autori
Babić, Marko ; Kalafatović, Daniela
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, znanstveni
Skup
European Rosettacon 2022
Mjesto i datum
Varšava, Poljska, 10.05.2022. - 13.05.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Microenvironments ; alignment ; enzymes ; catalytic
Sažetak
Structural and primary sequence analysis is required to determine the drivers of ester hydrolase catalytic function. Current sequence alignment methods such as Clustal Omega and the alfa-carbon-based structural alignment do not account for active sites. To correct this, we have developed a method that aligns primary sequences based on the catalytic residues in the active sites. To complement primary sequence alignment, we also developed a structural alignment method that aligns all catalytic residue atoms between two or more enzymes.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
--UIP-2019-04-7999 - Dizajn katalitički aktivnih peptida i peptidnih nanostruktura (UIP-2019-04) (DeShPet) (Kalafatović, Daniela) ( CroRIS)
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
