Naslov
Validation of New Systemic Lupus Erythematosus Classification Criteria

Autori
Aringer, M. ; Costenbader, K.H. ; Brinks, R. ; Boumpas, D. ; Daikh, D. ; Jayne, D. ; Kamen, D. ; Mosca, M. ; Ramsey-Goldman, R. ; Smolen, J.S. ; Wofsy, D. ; Diamond, B. ; Jacobsen, S. ; McCune, W.J. ; Ruiz-Irastorza, G. ; Schneider, M. ; Urowitz, M.B. ; Bertsias, G. ; Hoyer, B. ; Leuchten, N. ; Tani, C. ; Tedeschi, S. ; Touma, Z. ; Anić, Branimir ; Assan, F. ; Chan, T.M. ; Clarke, A.E. ; Crow, M.K. ; Czírják, L. ; Doria, A. ; Graninger, W. ; Hasni, S. ; Izmirly, P. ; Jung, M. ; Kiss, B. ; Mariette, X. ; Padjen, Ivan ; Pego- Reigosa, J.M. ; Romero-Díaz, J. ; Rúa-Figueroa, I. ; Seror, R. ; Stummvoll, G. ; Tanaka, Y. ; Tektonidou, M. ; Vasconcelos, C. ; Vital, E. ; Wallace, D.J. ; Yavuz, S. ; Naden, R.P. ; Dörner, T. ; Johnson, S.R.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ACR/ARP Abstracts 2018 / - , 2018

Skup
2018 ACR/ARHP Annual Meeting

Mjesto i datum
Chicago (IL), Sjedinjene Američke Države, 19.10.2018. - 24.10.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
SLE ; classification criteria

Sažetak
Background/Purpose: Correct classification of patients with systemic lupus erythematosus (SLE) is critical for clinical trials and clinical and translational science. The ACR 1997 criteria were criticized for their suboptimal sensitivity. The Systemic Lupus International Cooperating Clinics (SLICC) 2012 criteria increased sensitivity, but at the price of reduced specificity. This and further advances in the field led to the current four phase SLE criteria project. Following an item generation phase and item reduction via a Delphi and a nominal group exercise (1), the provisional criteria were derived from a multicriteria decision analysis exercise (2). These criteria were hence simplified and validated in a large international cohort. Methods: A large international cohort of 2, 321 patients was collected from 23 SLE expert centers, contributing up to 100 patients with SLE and with non-SLE, each. Diagnoses were verified by 3 independent reviewers for 1, 193 SLE and 1, 059 non- SLE patients. 501 randomly selected SLE and 500 non-SLE patients formed the derivation cohort. All other patients with confirmed SLE or non-SLE diagnosis formed the validation cohort. Sensitivity and specificity were compared to the ACR 1997 and the SLICC 2012 criteria. Results: The criteria were fine-tuned and simplified, using ANA of ≥1:80 as entry criterion and a classification threshold of 10. Items can only be counted for classification if there is no more likely cause, and at least one clinical item must be present.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA