Naslov
Stimulation of growth factor synthesis in skin wounds using tissue extract (G-90) from the earthworm Eissenia foetida

Autori
Grdiša, Mira ; Popović, Maja ; Hrženjak, Terezija

Izvornik
Cell biochemistry and fuction (0263-6484) 22 (2004), 6; 373-378

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
earthworm; G-90; growth factors; EGF; FGF

Sažetak
Growth factors are biologically active mediators that bind to specific receptors on target cells and regulate genes involved in cell growth, wound healing and regeneration. In the case of wound healing, a proper wound dressing is needed to cover the wound area, protect the damaged tissue, and if possible to activate cell proliferation and stimulate the healing process. In this study we examined the efficacy of glycolipoprotein tissue homogenate extract from Eisenia foetida (G-90) to activate signal transduction pathways, leading to wound healing. We measured the activation of EGF and FGF in healthy skin, in wounds with physiological healing and in wounds treated with G-90. The activation of EGF and FGF was measured during the first 24 hrs of wound healing under physiological conditions and treatment with G-90. In both cases an increased concentration of EGF and FGF were observed 6 hrs after wounding. In comparison with healthy skin, the concentration of EGF increased ten fold and FGF five fold in wounds treated with G-90 (10 ng/ml). Healing in physiological conditions resulted in two fold increasing of EGF and 1.5 fold of FGF.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina

POVEZANOST RADA