Naslov
Does one week of whole breast radiotherapy have to be a new standard of care?

Autori
Antunac, Katarina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2th congress of croatian society for plastic, reconstructive and aesthetic surgery (CSPRAS) with international participation ; 8th congress of croatian senologic society (CSS) with international participation 4th international congress of plastic surgery “fellows in science- Book of abstracts / - , 2022, 73-73

Skup
8. kongres Hrvatskog senološkog društva- HSD s međunarodnim sudjelovanjem

Mjesto i datum
Dubrovnik, Hrvatska, 03.05.2022. - 08.05.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Recenziran

Ključne riječi
breast cancer radiotherapy, whole breast radiotherapy (WBRT),

Sažetak
Whole breast radiotherapy after primary surgery reduces the risks of local and distant relapse and prolongs overall survival in the majority of patients. That risk reduction depends on both disease and patient’s characteristics ; therefore adjuvant radiotherapy is always individualised and risk adapted. Standard fractionation- 50 Gy in 2 Gy daily fractions during 5 weeks- has been standard of care for decades. Hypofractionation stands for use of daily fractions higher than 2 Gy. In the last 10- 15 years, upon results of START A and START B trial, adjuvant radiotherapy in 15 daily fractions of 2.67 Gy during three weeks has become a new standard of care. Except shorter duration and less toxicity, it also provides better control of the disease, most probably due to shorter overall treatment time. In 2020 results of Fast- forward trial comparing one week of whole breast radiotherapy (5x 5.4 Gy or 5x 5.2 Gy) with three-week radiotherapy in patients with pT1-3N0-1M0 breast cancer has been published. Target volume consisted of the conserved breast or post-mastectomy chest wall, without lymphatic drainage. Results have shown similar disease control and late toxicity and lower acute toxicity with one week regimen. One- week schedule is more convenient for both patients and caregivers and its use can increase access to radiotherapy. Due to narrow toxicity window of this regimen, strict dose- volume constraints and verification imaging requirements have to be fulfilled prior to introducing this method into routine practice.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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