Naslov
Diversity of oxacillinases and sequence types in carbapenem resistant acinetobacter baumannii from Austria
(Diversity of oxacillinases and sequence types in carbapenem resistant acinetobacter baumannii from Austria)

Autori
Grisold, Andrea ; Luxner, Josefa ; Bedenić, Branka ; Diab-Elschahawi, Magda ; Berktold, Michael ; Wechsler-Fordos, Agnes ; Zarfel, Gernot

Izvornik
International journal of environmental research and public health (1661-7827) 18 (2021), 4; 2171, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acinetobacter baumannii ; acinetobacter pittii ; OXA carbapenemases ; OXA-143 ; OXA-23 ; meropenem ; imipenem

Sažetak
Carbapenem-resistant Acinetobacter baumannii is a significant health problem worldwide. A multicenter study on A. baumannii was performed to investigate the molecular epidemiology and the genetic background of carbapenem resistance of A. baumannii isolates collected from 2014-2017 in Austria. In total, 117 non-repetitive Acinetobacter spp. assigned to A. baumannii (n= 114) and A. pittii (n=3) were collected from four centers in Austria. The isolates were uniformly resistant to piperacillin/tazobactam, ceftazidime and carbapenems, resistance rate to imipenem and meropenem was 97.4% and 98.2%, respectively. High susceptibility rates were observed for colistin (94.7%) and tigecycline (93.0%). Fifty-three (46.5%) harboured gene for OXA-58-like and 47 (41.2%) tested positive for OXA-23-like carbapenemase. OXA-24-like gene was found in 12 isolates (10.5%) only. In contrast, none of the isolates harboured genes encoding for MBL, KPC or GES carbapenemases. The population structure of A. baumannii isolates from Austria was found to be very diverse. Twenty-five different ST were identified. The most frequent was ST195 found in 15.8% of the isolates, followed by ST218 and ST231 equally found in 11.4%. Two new ST types, ST2025 and ST2016 were detected. In one A. pittii isolate for the first time OXA-143-like gene was detected in Austria.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA