Naslov
Retrospective analysis of Ki-67 antigen expression in paraffin tissue blocks of laryngeal squamous cell carcinoma

Autori
Fumić-Dunkić, Lidija ; Katić, Vladimir ; Janjanin, Saša ; Klapan, Ivica ; Šimunćić, Anamarija ; Včev, Aleksandar

Izvornik
American journal of otolaryngology (0196-0709) 24 (2003), 2; 106-110

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adult aged ; aged ; 80 and over ; biopsy ; needle carcinoma ; squamous cell ; squamous genetics ; squamous mortality ; squamous pathology ; squamous surgery ; case-control studies ; comparative study ; female ; gene expression regulation ; neoplastic ; genetic predisposition to disease ; human Ki-67 antigen

Sažetak
The level of Ki-67 antigen expression has been proven to correlate with cellular proliferation. The aim of the study was to show correlation of Ki-67 expression with the clinical stage and its predictive value for the prognosis of laryngeal carcinoma. The study included 48 patients with surgically removed carcinoma of the larynx. Study results pointed to a significant difference in the mean value of Ki-67 reactivity between the study and control group consisting of cadaveric laryngeal tissue free from the disease. Correlation was found between the TNM stage of carcinoma and percentage of Ki-67-labeled cells. A significant correlation was also observed between Ki-67 reactivity at the time of laryngeal surgery and 2-year clinical outcome of the disease. Ki-67 reactivity was significantly higher in the group of patients with disease remission compared with the control group but was significantly lower as compared with the group of patients with poor outcome.

Izvorni jezik
Engleski

POVEZANOST RADA