Naslov
Changes in CO ₂ during acute hypoxia in immature and adult rabbits and the development of apnea

Autori
Stucke, Astrid G ; Stuth, Eckehard A ; Mustapic, Sanda ; Radocaj, Tomislav ; Zuperku, Edward J

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Experimental Biology 2010

Mjesto i datum
Anaheim (CA), Sjedinjene Američke Države, 24.04.2010. - 28.04.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
etCO2 ; Hypoxic ventilatory response ; apnea

Sažetak
Hypoxia can lead to apnea in immature and adult rabbits. Also, a decrease in expiratory CO2 (etCO2) is routinely observed during controlled ventilation. This study evaluated the relationship between etCO2 and development of apnea during acute hypoxia (FiO2 0.08–0.1, 5–8 min). Hypoxic ventilatory responses (HVRs, n=124), as determined from the phrenic neurogram, were observed in 25 immature (< 30d) and 17 adult anesthetized or decerebrate, paralyzed, ventilated, and isothermic rabbits. EtCO2 correlated well with arterial PaCO2. 27% of the HVRs included apneas while 73% showed a marked decrease in rate. EtCO2 during control conditions (52–59 mmHg) and hypoxia (43–46 mmHg) was similar in all animals. There was no difference in the etCO2 decrease in immatures whether apneic or not (−16±3% vs. −17±1%), while the etCO2 decrease in adults was greater with apnea (−26±4% vs. −14±1%). Following termination of hypoxia, all animals showed a marked, temporary increase (7–14%) in etCO2 above prehypoxia control. The results suggest that hypoxia-induced apnea in adult rabbits correlates with a greater decrease in etCO2. The marked increase in etCO2, posthypoxia, suggests that this may be mediated by a decrease in cardiac output or change in organ blood flow pattern. The lack of a correlation between apnea and drop in etCO2 in immature rabbits may be due to developmental age. Supported by departmental funds.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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