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Pregled bibliografske jedinice broj: 1200335

Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern

Radocaj, Tomislav; Mustapic, Sanda; Stucke, Astrid G.; Stuth, Eckehard A.; Zuperku, Edward J.
Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern // Experimental Biology 2009
New Orleans (LA), Sjedinjene Američke Države: John Wiley & Sons, 2009. 960.7, 1 doi:10.1096/fasebj.23.1_supplement.960.7 (poster, međunarodna recenzija, sažetak, znanstveni)

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Naslov
Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern

Autori
Radocaj, Tomislav ; Mustapic, Sanda ; Stucke, Astrid G. ; Stuth, Eckehard A. ; Zuperku, Edward J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Experimental Biology 2009

Mjesto i datum
New Orleans (LA), Sjedinjene Američke Države, 18.04.2009. - 22.04.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pBC region ; 5HT ; breathing ; 8OH-DPAT

Sažetak
Previous studies suggest the presence of serotonin (5HT), dopamine (DA), and adrenergic receptors within the pBC region, but where these neuromodulators produce their principal effects on breathing remains unclear. The effects of local microinjections of 5HT (5mM), norepinephrine (NE ; 5mM) and DA (5mM) into the VRC including the pBC on inspiratory (TI) and expiratory durations (TE) and peak phrenic activity (PPA) were studied in decerebrate, vagotomized, ventilated, paralyzed dogs (n=6). The locations of the VRC and pBC were determined by neuronal recordings and phrenic responses to glutamate agonist DLH (20mM, ~40 nl) microinjections. Unilateral injections (~100 nl) were made in 1 mm increments from the obex to 7mm rostral. The selective 5HT2a agonist (DOI, 0.2mM) and 5HT1a agonist (8OH-DPAT, 0.2mM) were used in a similar protocol (n=7) and subsequently given iv. All amine agonists produced no significant changes in TI, TE, and PPA at any location within the VRC, while DLH injections produced significant changes. DOI (256 mcg/kg iv) produced a 10.3±5.4% increase in TI with no changes in TE and PPA, while 8OH- DPAT (74 mcg/kg iv) decreased TI and TE to 67.1±4.5% and 62.3±7.2%, respectively with no change in PPA. These data suggest that the exogenous biogenic amines produce their effects on the breathing pattern at locations outside the VRC and pBC in dogs. Supported by VA Med. Res. and NIH GM059234 funds.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Profili:

Avatar Url Tomislav Radočaj (autor)

Poveznice na cjeloviti tekst rada:

doi faseb.onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Radocaj, Tomislav; Mustapic, Sanda; Stucke, Astrid G.; Stuth, Eckehard A.; Zuperku, Edward J.
Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern // Experimental Biology 2009
New Orleans (LA), Sjedinjene Američke Države: John Wiley & Sons, 2009. 960.7, 1 doi:10.1096/fasebj.23.1_supplement.960.7 (poster, međunarodna recenzija, sažetak, znanstveni)
Radocaj, T., Mustapic, S., Stucke, A., Stuth, E. & Zuperku, E. (2009) Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern. U: Experimental Biology 2009 doi:10.1096/fasebj.23.1_supplement.960.7.
@article{article, author = {Radocaj, Tomislav and Mustapic, Sanda and Stucke, Astrid G. and Stuth, Eckehard A. and Zuperku, Edward J.}, year = {2009}, pages = {1}, DOI = {10.1096/fasebj.23.1\_supplement.960.7}, chapter = {960.7}, keywords = {pBC region, 5HT, breathing, 8OH-DPAT}, doi = {10.1096/fasebj.23.1\_supplement.960.7}, title = {Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern}, keyword = {pBC region, 5HT, breathing, 8OH-DPAT}, publisher = {John Wiley and Sons}, publisherplace = {New Orleans (LA), Sjedinjene Ameri\v{c}ke Dr\v{z}ave}, chapternumber = {960.7} }
@article{article, author = {Radocaj, Tomislav and Mustapic, Sanda and Stucke, Astrid G. and Stuth, Eckehard A. and Zuperku, Edward J.}, year = {2009}, pages = {1}, DOI = {10.1096/fasebj.23.1\_supplement.960.7}, chapter = {960.7}, keywords = {pBC region, 5HT, breathing, 8OH-DPAT}, doi = {10.1096/fasebj.23.1\_supplement.960.7}, title = {Effects of local microejection of biogenic amines into the pre‐Botzinger complex (pBC) and adjacent ventral respiratory column (VRC) on the canine breathing pattern}, keyword = {pBC region, 5HT, breathing, 8OH-DPAT}, publisher = {John Wiley and Sons}, publisherplace = {New Orleans (LA), Sjedinjene Ameri\v{c}ke Dr\v{z}ave}, chapternumber = {960.7} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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