Naslov
THE ROLE OF APOTOSIS IN A CARCINOGENESIS OF PROSTATE CARCINOMA

Autori
Heinzel, R. ; Baličević, D. ; Belicza, M.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
7th LJUDEVIT JURAK INTERNATIONAL SYMPOSIUM ON COMPARATIVE PATHOLOGY BOOK OF ABSTRACTS / Belicza Mladen - Zagreb : Foto Quick, 1996

Skup
7th LJUDEVIT JURAK INTERNATIONAL SYMPOSIUM ON COMPARATIVE PATHOLOGY

Mjesto i datum
Zagreb, Hrvatska, 07.06.1996. - 08.06.1996

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
APOTOSIS; PROSTATE CARCINOMA

Sažetak
To determine the volume and numeric density of apoptotic bodies in hyperplasias and prostatic carcinomas we have examined all histological slides stereologically using Weibel's test system M 42, at PF of 400X. In our investigation of numeric density of apoptotic bodies in all types of hyperplasias as a group and in prostate carcinomas we have found statistically significant bigger number of apototic bodies in hyperplasias than in welldifferentiated prostate carcinomas G1. This finding implicated our further investigation of apoptotic bodies in different types of hyperplasias of the prostate including atypical hyperplasia and PIN. Our finding of greater number of apoptotic bodies expressed by numeric and volume density in the postsclerotic and basal cell types of prostate hyperplasias implicates ćhe possible role of prostate stroma in carcinogenesis of prostate carcinoma. Of special interest is big number of apoptotic bodies found in basal cell hyperplasias what implicates possibility of further influence of prostate stroma in the pathogenesis of this type of hyperplasia and possible transformation in prostate carcinoma. Many previous investigations have suggested that number of apoptotic bodies may be a good parameter of tumor growth. On this point of view our findings of great number of apoptotic bodies in the postsclerotic and the basal cell hyperplasias correlate with the opinion of other investigators who pointed out these two hyperplasias as precancerous conditions. This implicates the hypothesis that carcinogenesis in a prostate is not intraluminar and glandular process only

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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