Naslov
Effect of the multiple surfactant system on physical properties and in vitro release of mupirocin from the cream base

Autori
Tadić, Zdravka ; Golja Gašparović Petra ; Ujdur, Iva ; Ferderber, Kristina ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Farmaceutski vestnik / Mrhar, Aleš ; Baumgartner, Saša - Ljubljana : Slovenian Pharmaceutical Society, 2008, 298-300

Skup
7th Central European Symposium on Pharmaceutical Technology and Biodelivery System,

Mjesto i datum
Ljubljana, Slovenija, 18.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mupirocin, cream, surfactants, in vitro release

Sažetak
The ratio of emulsifiers in formulation can affect, apart from the emulsion stability and viscosity, the drug release profile. Therefore, in order to achieve the desired properties of the formulation, amount of emulsifiers have to be carefully optimized. The aim of the present study was to investigate the influence of the emulsifiers ratio in the cream formulation on the release profile of active substance, emulsion stability and its viscosity. Ratio of Cetyl alcohol, Stearyl alcohol and Cetomacrogol 1000 have great impact on viscosity, release rate of mupirocin from cream base, as well as stability of the emulsion. In order to achieve good physical properties and desired release of mupirocin, the concentrations of mixed emulsifiers should carefully optimized considering all these three parameters.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA