Pregled bibliografske jedinice broj: 1198791
Early compartmentalization and laminar rhythm of future projection neuron markers during the human early cortical plate stage
Early compartmentalization and laminar rhythm of future projection neuron markers during the human early cortical plate stage // MNS Full Proceedings
Dubrovnik, Hrvatska, 2022. str. 158-158 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1198791 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Early compartmentalization and laminar rhythm of
future projection neuron markers during the human
early cortical plate stage
Autori
Kopić, Janja ; Junaković, Alisa ; Rašin, Mladen Roko ; Kostović, Ivica ; Krsnik, Željka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
MNS Full Proceedings
/ - , 2022, 158-158
Skup
8th Mediterranean Neuroscience Society Conference
Mjesto i datum
Dubrovnik, Hrvatska, 29.05.2022. - 02.06.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
early cortical plate, human brain development, projection neurons
Sažetak
The precise coordination of differential gene expression involved in fundamental neurogenetic and histogenetic processes is essential for development of the human fetal brain. Corticogenesis relies upon precise timing and location of cell proliferation and migration, followed by neuronal differentiation and molecular identity attaining. Furthermore, the correct establishment of the future six-layered human neocortex depends on the appearance of transient compartments and accurate developmental program during the first condensation of cortical plate (CP). Importantly, future projection neurons need to obtain the exact laminar position in order to mature and specify for their role. In this study, we aimed to monitor the early expression pattern of projection neuron markers, i.e. future cortical layer-specific markers (CELF1, TBR1, CTIP2, TLE4) during the development of early cortical plate. In order to reveal laminar shifts and molecular specification of major classes of neurons, we performed immunofluorescence (IF) of these markers on prenatal postmortem human brain tissue. Moreover, we used additional markers (Ki67, PAX6, TBR2) to track stages of cell differentiation during the early cortical plate period. Our results showed that projection neuron markers are expressed during early cortical plate stage, suggesting their involvement in neurogenetic processes responsible for establishment of six- layered human cerebral cortex.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
