Naslov
Morphological and functional characterization of human microglia in transient structures of the developing brain

Autori
Menassa, David ; Kopić, Janja ; Junaković, Alisa ; Krsnik, Željka ; Kostović, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
MNS Full Proceedings / - , 2022, 148-148

Skup
8th Mediterranean Neuroscience Society Conference

Mjesto i datum
Dubrovnik, Hrvatska, 29.05.2022. - 02.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
human brain development ; microglia ; subplate

Sažetak
Prenatal human brain develops via dynamic progressive and reorganization processes of histogenetic events. Transient structures enable the development of specific and unique morphology and connectivity pathways of the human cortical and subcortical structures. Microglial morphology varies in transient layers of the future neocortex and transitional structures during brain development. To date, the role of microglia in morphogenetic events during human brain development remains underexplored. Differences in microglial morphology are likely coupled with a specific function serving the purpose of shaping the neurodevelopmental landscape. Therefore, a proper characterization of morphological microglial states is required in areas of neurogenetic importance. In this study, we aimed to analyze different phenotypes of microglia in transient, human characteristic structures during the period of their existence and gradual disappearance. We expect to unravel the possible role of microglia in these particular processes of transient structures which are important for further cortical and connectivity development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA